Phospholipase A2 (PLA2), CAS No.9001-84-7

CAS: 9001-84-7 Cat. No.: P1522973 Numero EC: 232-637-7 PubChem CID: 135295618

GRADE & PURITY Bioactive, Recombinant, ActiBioPure™, High Performance, EnzymoPure™, ≥10 U/mL

Accession #

P00592

Bioactivity

≥10 U/mL

Panoramica

Phospholipase A2 (PLA2) is a calcium-dependent, heat-stable enzyme that catalyzes the hydrolysis of glycerophospholipids at the sn-2 position of cellular membranes, thereby releasing Arachidonic Acid (AA). Phospholipase A2 is a key mediator in the biosynthesis of pro-inflammatory lipid mediators, critically involved in inflammatory processes. Phospholipase A2 can be used for cardiovascular and inflammatory diseases research.

Specifications

Product Name

Phospholipase A2 (PLA2), CAS No.9001-84-7

Sinonimi

phospholipase A2 | lecithinase A | phosphatidase | phosphatidolipase | phosphatidylcholine 2-acylhydrolase | PLA2G1B | PLA2 | sPLA(2)-IB

Grado

ActiBioPure™, Bioactive, High Performance, Recombinant, EnzymoPure™

Specifiche e purezza

Bioactive, Recombinant, ActiBioPure™, High Performance, EnzymoPure™, ≥10 U/mL

Meccanismi biochimici e fisiologici

Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position. Requires Ca2+.

Bioattività

≥10 U/mL

Numero d'ordine

P00592

CAS

9001-84-7

Numero della Commissione Enzimi

EC 3.1.1.4

Tipo di molecola

Enzima

Stoccaggio e spedizione

Concentrazione

≥10 U/mL

Condizioni di conservazione di stoccaggio

Store at -20°C,Avoid repeated freezing and thawing

Spedito in

Ice chest + Ice pads

Stabilità e conservazione

Store at 2-8℃ short term (12 months). Store at -20℃ long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Definizione dell'unità

One unit will hydrolyze 1.0 umole of soybean L-alpha-phosphatidylcholine to L-alpha-lysophosphatidylcholine and a fatty acid per min at pH 8.0 at 37℃.

Obiettivi associati (umani)

PLA2G1B Tchem Phospholipase A2 (0 Activities)

Discover Target: PLA2G1B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Riferimenti

1. Cao Wenbo, Cheng Simin, Yang Jing, Feng Jiaxin, Zhang Wenpeng, Li Zishuai, Chen Qinhua, Xia Yu, Ouyang Zheng, Ma Xiaoxiao.  (2020)  Large-scale lipid analysis with C=C location and sn-position isomer resolving power.  Nature Communications,  11  (1): (1-11).  [PMID:31953382] [10.1038/s41467-019-14180-4]

2. Yongjian Wen, Yuying Li, Tingting Liu, Lijia Huang, Linbo Yao, Dan Deng, Wenjuan Luo, Wenhao Cai, Shaoqi Zhong, Tao Jin, Xinmin Yang, Qiqi Wang, Wen Wang, Jing Xue, Rajarshi Mukherjee, Jiwon Hong, Anthony R. Phillips, John A. Windsor, Robert Sutton, Fei Li, Xin Sun, Wei Huang, Qing Xia.  (2024)  Chaiqin chengqi decoction treatment mitigates hypertriglyceridemia-associated acute pancreatitis by modulating liver-mediated glycerophospholipid metabolism.  PHYTOMEDICINE,      [PMID:39217651] [10.1016/j.phymed.2024.155968]

3. Xu Shuling, Zhu Zhijun, Delafield Daniel G., Rigby Michael J., Lu Gaoyuan, Braun Megan, Puglielli Luigi, Li Lingjun.  (2024)  Spatially and temporally probing distinctive glycerophospholipid alterations in Alzheimer’s disease mouse brain via high-resolution ion mobility-enabled sn-position resolved lipidomics.  Nature Communications,  15  (1): (1-18).  [PMID:39048572] [10.1038/s41467-024-50299-9]

4. Jihang Zhang, Siwen Ji, Jinming Zhang, Yihui Luo, Yanjun Chen, Jinglan Wu, Pengpeng Yang, Fengxia Zou, Hanjie Ying, Wei Zhuang.  (2025)  Surface chemistry-driven lipase activation: insights from spectroscopy and molecular simulations.  BIORESOURCE TECHNOLOGY,      [PMID:40712940] [10.1016/j.biortech.2025.133035]

5. Qi Qin, Rong-Yao Gao, Yi-Qian Li, Rui Zhang, Yao Lu, Nami Yamano, Xiao-Chun Qin, Dan-Hong Li, Jian-Ping Zhang.  (2025)  Effect of Oxygen Exposure on the Triplet Excitation Dynamics of the Monomeric LHCII Complex from Spinach.  JOURNAL OF PHYSICAL CHEMISTRY B,      [PMID:40923864] [10.1021/acs.jpcb.5c03398]