PHT-7.3 - 10mM in DMSO , CAS No.1614225-93-2

CAS: 1614225-93-2 Cat. No.: P655934 Molecular Weight: 433.52 PubChem CID: 76287542

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

PHT-7.3 is a selective inhibitor of connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain ( K d =4.7 μM). PHT-7.3 inhibits mut-KRas, but not wild-type KRas cancer cell and tumor growth and signaling. PHT-7.3 has antitumor activity

In Vivo

PHT-7.3 (200 mg/kg; i.p.; daily; for 20 days) exhibits cytostatic antitumor activity in the mut-KRas(G12S) A549 xenograft and mut-KRasG12V H441 xenograft . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female NOD-SCID mice (mut-KRas A549 NSCLC xenografts, mut-KRas H441 NSCLC xenografts) Dosage: 200 mg/kg Administration: Intraperitoneal injection, daily, for 20 days Result: Exhibited cytostatic antitumor activity in the mut-KRas(G12S) A549 xenograft and mut-KRasG12V H441 xenograft .

IC50& Target:Cnk1 PH-domain

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

PHT-7.3 is a selective inhibitor of connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain ( K d =4.7 μM). PHT-7.3 inhibits mut-KRas, but not wild-type KRas cancer cell and tumor growth and signaling. PHT-7.3 has antitumo

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Isomeric SMILES: CC1=CC=C(C=C1)C2=CSC(=N2)CN3C(=O)C4=CC=CC=C4C(=N3)CC5OCCCO5
• PubChem CID: 76287542
• Molecular Weight: 433.52

Associated Targets(Human)

CNKSR1 Tchem Connector enhancer of kinase suppressor of ras 1 (2 Activities)

Discover Target: CNKSR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)