10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Panoramica
PI3Kδ-IN-1 is a potent, selective, and efficacious PI3Kδ inhibitor with an IC 50 of 1.7 nM.
In Vitro
PI3Kδ-IN-1 (compound 52) shows >100-fold selectivity over the other PI3K isoforms. Kinome selectivity is also excellent with >660-fold selectivity over MNK1 and others in HTRF assays. Importantly, PI3Kδ-IN-1 has an improved human/rodent in vitro stability correlation and a good permeability profile. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
PI3Kδ-IN-1 (2, 5 mg/kg, orally b.i.d. for 42 days) shows greater than 50% suppression of paw swelling in mice. PI3Kδ-IN-1 has an EC 50 of 10 nM at 24 h ( ED 50 of ∼1.25 mg/kg) in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male DBA/1 mice (20−25g) Dosage: 0.5, 2, 5 mg/kg Administration: Oral b.i.d. for 42 days, Result: A dose dependent reduction of the clinical score was observed. Doses of 2 and 5 mg/kg showed greater than 50% suppression of paw swelling .
IC50& Target:IC50: 1.7 nM (PI3Kδ)
Specifications
Specifiche e purezza
10mM in DMSO
Meccanismi biochimici e fisiologici
PI3Kδ-IN-1 is a potent, selective, and efficacious PI3Kδ inhibitor with an IC 50 of 1.7 nM.
Condizioni di conservazione di stoccaggio
Store at -80°C
Spedito in
Dry ice packs + Cold packs
Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.
Certificati (CoA, COO, BSE/TSE e tabella di analisi)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
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Recensioni
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Domande frequenti
How should this product be stored?
Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 1911564-39-0, the molecular formula is C22H20F3N7O2, and the molecular weight is 471.44 g/mol.
How is this product shipped?
This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.
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