Pifusertib hydrochloride - Moligand™, ≥98% , Serine/threonine-protein kinase AKT negative allosteric modulator, CAS No.2930090-28-9, Serine/threonine-protein kinase AKT negative allosteric modulator

CAS: 2930090-28-9 Cat. No.: P612832 Formula: C₂₆H₂₅ClN₄O₂ Peso molecolare: 460.96

GRADE & PURITY Moligand™, ≥98%

Synonyms

G17865 | MS-28465 | HY-19934A | SCHEMBL23122660 | SCHEMBL23122658 | TAS-117 hydrochloride

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Panoramica

Pifusertib (TAS-117) hydrochloride is a potent, selective allosteric Akt inhibitor (with IC50s of 4.8, 1.6, and 44 nM for Akt1, 2, and 3, respectively). Pifusertib hydrochloride triggers anti-myeloma activities and enhances fatal endoplasmic reticulum (ER) stress induced by proteasome inhibition. Pifusertib hydrochloride induces apoptosis and autophagy.

Specifications

Sinonimi

G17865 | MS-28465 | HY-19934A | SCHEMBL23122660 | SCHEMBL23122658 | TAS-117 hydrochloride

Specifiche e purezza

Moligand™, ≥98%

Condizioni di conservazione di stoccaggio

Store at -20°C,Argon charged

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

INHIBITOR, NEGATIVE ALLOSTERIC MODULATOR

Meccanismo d'azione

Serine/threonine-protein kinase AKT negative allosteric modulator

Purezza

≥98%

Nomi e identificatori

Sorrisi canonici

CC1(CC(C1)(C2=CC=C(C=C2)C3=C(N4COC5=C(C4=N3)C=NC=C5)C6=CC=CC=C6)N)O.Cl

CAS alternativo

1402602-94-1

Peso molecolare

460.96

Reaxy-Rn

26516249

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=26516249&ln=

Obiettivi associati (umani)

AKT3 Tchem RAC-gamma serine/threonine-protein kinase (0 Activities)

Discover Target: AKT3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKT2 Tchem RAC-beta serine/threonine-protein kinase (1 Activities)

Discover Target: AKT2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKT1 Tchem RAC-alpha serine/threonine-protein kinase (1 Activities)

Discover Target: AKT1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Proprietà chimiche e fisiche

• Sensibilità: Moisture sensitive.

Domande frequenti

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2930090-28-9, the molecular formula is C26H25ClN4O2, and the molecular weight is 460.96 g/mol.

How should this product be stored?

Store at ?20 °C under argon. It is supplied under an argon blanket; reseal under inert gas after each use.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.