Plasmin from Human Plasma, CAS No.9001-90-5

CAS: 9001-90-5 Cat. No.: np001028 Peso molecolare: 81000

GRADE & PURITY Bioactive, Native, Lyophilized powder, EnzymoPure™, ≥90%(SDS-PAGE), ≥15 U/mg protein; Pre-lyophilization Protein Concentration: See COA

Accession #

P00747

Bioactivity

≥15 U/mg protein

Panoramica

Plasmin is a serine protease central to the breakdown of blood clots through fibrinolysis, where it degrades fibrin, the main structural component of clots. Beyond its primary role in fibrinolysis, plasmin also participates in fibrinogenolysis, complement activation, tissue remodeling, and inflammation. It is synthesized in the liver as the inactive precursor plasminogen, which circulates in the blood and is activated at sites of clot formation by tissue plasminogen activator (tPA), urokinase, or therapeutically by streptokinase. Structurally, plasmin contains multiple domains, including kringle domains that facilitate binding to lysine residues on fibrin and cell surfaces, enhancing its targeting and activity.

Common research uses

Functionally, plasmin not only dissolves clots but also activates collagenases, complement components (such as C1 and C5), and cleaves extracellular matrix proteins, contributing to processes like embryonic development, wound healing, and tumor invasion. Deficiencies or dysregulation of plasmin activity can lead to thrombosis or rare disorders such as plasminogen deficiency, which impairs wound healing and tissue repair. Clinically, plasmin and its activators are used as thrombolytic agents to treat conditions like myocardial infarction, stroke, and pulmonary embolism, and ongoing research explores engineered plasmin variants for safer, more targeted therapies.

Common uses include IVD Assay standards, calibrators and controls, coagulation research, cardiovascular research, therapeutics development.

Specifications

Product Name

Plasmin from Human Plasma, CAS No.9001-90-5

Grado

Bioactive, Lyophilized powder, Native, EnzymoPure™

Specifiche e purezza

Bioactive, Native, EnzymoPure™, Lyophilized powder, ≥90%(SDS-PAGE), ≥15 U/mg protein; Pre-lyophilization Protein Concentration: See COA

Meccanismi biochimici e fisiologici

Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It

Bioattività

≥15 U/mg protein

Numero d'ordine

P00747

Peso molecolare previsto

81,000Da

CAS

9001-90-5

Numero della Commissione Enzimi

EC 3.4.21.7

Tipo di molecola

Enzima

Stoccaggio e spedizione

Forma

Lyophilized from 20 mM NaP04, pH 7.4, with 10 mg/ml D-Mannitol and 10 mg/ml NaCl.

Concentrazione

≥15 U/mg protein; Pre-lyophilization Protein Concentration: See COA

Ricostituzione

After centrifugation, we suggest addition of de-ionized water to the original volume (See COA), followed by gentle mixing to ensure adequate homogenization. If further dilution is required, please use the lyophilization buffer.

Condizioni di conservazione di stoccaggio

Store at -20°C,Avoid repeated freezing and thawing

Spedito in

Ice chest + Ice pads

Stabilità e conservazione

Store at -20℃ long term (>1 year). Upon reconstitution, it is recommended to aliquot. Avoid freeze/thaw cycle.

Definizione dell'unità

One unit is defined as the amount of enzyme that hydrolyzes one umole of tosyl-Gly-Pro-Lys-pNA per minute at 25°C, pH 7.8. Note: One unit=1.25 CU.