Poly-(L-lysine) - ≥98% , CAS No.28211-04-3

CAS: 28211-04-3 Cat. No.: P1523095 EC Number: 825-244-2 PubChem CID: 20719176

GRADE & PURITY ≥98%

Storage

Protected from light,Room temperature,Desiccated

Shipped In

Normal

Overview

Poly-L-lysine (ε - PL) is a kind of homomonomer polymer with 25-35 L-lysine residues produced by Streptomyces albulus. It has obvious inhibitory effect on Gram-positive and negative bacteria, yeasts, molds and viruses. It is widely used in food, daily chemical and pharmaceutical products. The product can be completely digested and absorbed by human body, decomposed into lysine necessary for human body, without any toxic and side effects.

Product Application

Application in food: at present, polylysine is widely used in food and beverage, such as cake, pastry, fast food, butter, salad dressing, beverage, wine, meat products, canned food, etc.; application in cosmetics and daily chemical products: cosmetics are easily contaminated by microorganisms in the process of production, storage and use. Cosmetics due to microbial pollution and deterioration, moldy, very harmful to human skin. Due to its broad-spectrum antibacterial activity, ε - PL can effectively inhibit the growth of various microorganisms and ensure the quality of products. ε - PL is a polymer of many amino acids, so it is also a kind of nutritional preservative, so it is green, safe and efficient. In addition, ε - PL is also widely used in toothpaste, mouthwash, soap, hand sanitizer, wipes, kitchen cleaning, women's sanitary napkins, baby diapers and other daily chemical products. Medical applications: ε - polylysine is rich in cations, has strong electrostatic force with anionic substances, and has good penetration to biofilm. Based on this characteristic, polylysine can be used as the carrier of some drugs, so it has been widely used in medical and pharmaceutical fields. The polymerization of ε - polylysine and aminomethylpurine can improve the therapeutic effect of drugs. It was found that the adsorption of high molecular weight poly (L-lysine) could reduce the critical voltage of cell membrane damage.

Specifications

Specifications & Purity

≥98%

Storage

Protected from light, Room temperature, Desiccated

Shipped In

Normal

Purity

≥98%

Names and Identifiers

• Canonical Smiles: CCCCCC(C(=O)NC)N
• IUPAC Name: 2-amino-N-methylheptanamide
• InChIKey: YLBHPLDJISPYOJ-UHFFFAOYSA-N
• INCHI: 1S/C8H18N2O/c1-3-4-5-6-7(9)8(11)10-2/h7H,3-6,9H2,1-2H3,(H,10,11)
• Isomeric SMILES: CCCCCC(C(=O)NC)N
• Alternate CAS: 25104-18-1
• PubChem CID: 20719176

Chemical and Physical Properties

• Solubility: ε - polylysine is soluble in water, colorless and tasteless, and does not affect food flavor.

References

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66. Ya-Qing Zhou, Xudong Deng, Zi-Xu Zhao, Xue-Ting Wang, Xiao-Qian Jin, Jun-Bin Xiong, Liang-Liang Chen, Wei-Hong Guo, Ren-Bin Zhou, Da-Chuan Yin.  (2025)  High-strength chitosan-sericin cryogel with synergistically reinforced networks for hemostasis.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40484092] [10.1016/j.ijbiomac.2025.145038]

67. Jing Zhao, Na Liu, Yating Zeng, Yiwen Zhang, Liyun Chen, Jianda Zhou, Bo Liu, Wancong Zhang, Shijie Tang.  (2025)  Asymmetric Janus Electrospun Nanofiber Wound Dressing Infused with Antibacterial and Anti-inflammatory Properties.  BIOMACROMOLECULES,      [PMID:41060049] [10.1021/acs.biomac.5c01166]

68. Zhiwei Chen, Xinyu Di, Heyan Chen, Shengnan Song, Siyi Zhu, Leer Cai, Yuqi Han, Yongshuai Kang, Dingchao Shen, Huirong Huang, Aimin Cai, Hailun Zheng, Qing Yao, Maoping Chu, Ruijie Chen, Longfa Kou.  (2025)  Inflammation-targeted nanoparticles modulate macrophage polarization for coronary therapy in Kawasaki disease.  JOURNAL OF CONTROLLED RELEASE,      [PMID:41135700] [10.1016/j.jconrel.2025.114350]

69. Dan Li, Huirong Cheng, Ling Xie, Hong Luo, Dandan Zhang, Jupeng Zhao, Yueming Jiang, Liang Gong.  (2025)  Physicochemical properties of edible oxidized gum arabic–polylysine crosslinked films and their effects on the postharvest preservation of litchi.  POSTHARVEST BIOLOGY AND TECHNOLOGY,      [PMID:] [10.1016/j.postharvbio.2025.114012]

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71. Yimeng Xie, Yuedi Yu, Zhengwei Cai, Jian Sun, Wei Bi, Fei Yang, Qianrong Zhou, Xingwen Wu, Ruixue Li, Keshi Zhu, Youcheng Yu, Wenguo Cui, Wenjuan Liu, Yang Sun.  (2025)  The injectable cationic double-crosslinked hydrogel facilitates bone regeneration and repair through sustained antibacterial activity.  Materials Today Bio,      [PMID:41281651] [10.1016/j.mtbio.2025.102461]

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75. Jiaying Yan, Panpan Wang, Jinlong Zhu, Xiaoqun Zhou, Han Wang, Shiyi Qiu, Zilin Su, Zhilin Zhang, Yu Hu, Jun Ma.  (2025)  Enhanced Antifouling Performance of Ultra-thin Antimicrobial Peptide Membrane through Chemical-crosslinking Layer-by-Layer Assembly.  WATER RESEARCH,      [PMID:41418612] [10.1016/j.watres.2025.125171]

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77. Xingyu Zhang, Yongping Liang, Junchao Zhu, Bowen Qiao, Baolin Guo, Lei Tian.  (2025)  Near-infrared-triggered photothermal/photodynamic anti-biofilm hydrogels encapsulated with antimicrobial peptide-modified copper-doped carbon quantum dots for methicillin-resistant Staphylococcus aureus-infected wounds healing.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.172049]

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79. Fengli Chai, Dou Wang, Fenggang Li, Saijie Wang, Yao Chen, Yongzhi Huang, Jiuxin Qu, Shuailong Zhang, Jiangjiang Zhang, Xingyu Jiang.  (2026)  Metal–Organic Framework@Gold Nanoparticles Enables Point-of-Care Diagnostics To Have Comparable Analytical Performance to Chemiluminescent Immunoassays.  ANALYTICAL CHEMISTRY,      [PMID:41507033] [10.1021/acs.analchem.5c04267]

80. Peifang Xu, Yiming Sun, Jun Huang, Yishu Zhang, Tong Zhou, Jiawei Wang, Pengjie Chen, Mingyu Xu, Yifan Zhou, Shan Yu, Juan Ye.  (2026)  A thermosensitive chitosan hydrogel enabled MnO2 nanozyme delivery with NO release for enhanced corneal repair.  Journal of Materials Chemistry B,      [PMID:41532353] [10.1039/D5TB02635K]

81. Jinhuan Li, Ling Cai, Zhen Fu, Xiaodong Zhu, Yanqiang Huang, Yuan Wu, Jin Chen.  (2026)  Biomineralized manganese-based cascade nanosystem for augmented combinational therapy of oral cancer and dual-modal imaging-guided diagnosis.  MATERIALS & DESIGN,      [PMID:] [10.1016/j.matdes.2026.115575]

82. Leiting Xin, Zhiyuan Hu, Ying Mao, Guan Wu, Wenxing Chen, Wangyang Lu.  (2026)  Biocompatible silk nanofibers with excellent antimicrobial and preservation properties by ε-polylysine grafting.  FOOD CHEMISTRY,      [PMID:41621314] [10.1016/j.foodchem.2026.148204]

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84. Xin Hu, Meiqi Feng, Chengjin Qi, Boran Li, Hongjuan He, Kai Li, Lu Chen, Boshu Ji, Haoran Yu, Yue Zhao, Tong Wu, Ruiheng Ma, Yuhao Dong, Yan Zhang, Qiong Wu.  (2026)  NAT10-mediated ac4C RNA acetylation stabilizes CXCL5/DEK mRNA to drive proliferation and metastasis in lung adenocarcinoma.  Cell Death & Disease,  17  (1): (326).  [PMID:41862454] [10.1038/s41419-026-08568-6]