Pomalidomide-C₆-CO₂H - ≥98% , CAS No.2225940-50-9

CAS: 2225940-50-9 Cat. No.: P464854 Formula: C₂₀H₂₃N₃O₆ Peso molecolare: 401.42 PubChem CID: 134589631

GRADE & PURITY ≥98%

Synonyms

Protein degrader building block for PROTAC research, 7-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)heptanoic acid, Crosslinker−E3 Ligase ligand conjugate, Template for synthesis of targeted protein degrader

Storage

Store at 2-8°C

Shipped In

Wet ice

Panoramica

Description

Protein degrader builiding block Pomalidomide-C6-CO2H enables the synthesis of molecules fortargeted protein degradation andPROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and an alkyl-chain crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blockswith a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Specifications

Sinonimi

Protein degrader building block for PROTAC research, 7-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)heptanoic acid, Crosslinker−E3 Ligase ligand conjugate, Template for synthesis of targeted protein degrader

Specifiche e purezza

≥98%

Informazioni legali

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Condizioni di conservazione di stoccaggio

Store at 2-8°C

Spedito in

Wet ice

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Purezza

≥98%

Nomi e identificatori

• Sorrisi canonici: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCCCCCC(=O)O
• IUPAC Name: 7-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]heptanoic acid
• InChIKey: USOIUAJFCJMMOE-UHFFFAOYSA-N
• INCHI: 1S/C20H23N3O6/c24-15-10-9-14(18(27)22-15)23-19(28)12-6-5-7-13(17(12)20(23)29)21-11-4-2-1-3-8-16(25)26/h5-7,14,21H,1-4,8-11H2,(H,25,26)(H,22,24,27)
• PubChem CID: 134589631
• Peso molecolare: 401.42

Proprietà chimiche e fisiche

• Peso molecolare: 401.400 g/mol
• XLogP3: 2.000
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 9
• Exact Mass: 401.159 Da
• Monoisotopic Mass: 401.159 Da
• Topological Polar Surface Area: 133.000 Ų
• Heavy Atom Count: 29
• Formal Charge: 0
• Complexity: 694.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1