Protein degrader building block for PROTAC research, 6-(2-(2-((6-Azidohexyl)oxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)hexanamide, Template for synthesis of targeted protein degrader, Crosslinker−E3 ligase ligand con
≥95% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Panoramica
Description
Protein degrader builiding block Pomalidomide-C6-PEG3-Butyl Azide enables the synthesis of molecules fortargeted protein degradation andPROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blockswith a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Specifications
Sinonimi
Protein degrader building block for PROTAC research, 6-(2-(2-((6-Azidohexyl)oxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)hexanamide, Template for synthesis of targeted protein degrader, Crosslinker−E3 ligase ligand con
Specifiche e purezza
≥95%
Informazioni legali
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Condizioni di conservazione di stoccaggio
Store at 2-8°C
Spedito in
Wet ice
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