Pomalidomide-PEG₂-butyl azide - ≥95%

Cat. No.: P463563

GRADE & PURITY ≥95%

Synonyms

2-(2-((6-Azidohexyl)oxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide, Protein degrader building block for PROTAC research, Crosslinker−E3 Ligase ligand conjugate, Template for synthesis of targeted protein degrader, Pom

Storage

Store at 2-8°C

Shipped In

Wet ice

Panoramica

Description

Protein degrader builiding block Pomalidomide-PEG2-Butyl Azide enables the synthesis of molecules fortargeted protein degradation andPROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blockswith a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Specifications

Sinonimi

2-(2-((6-Azidohexyl)oxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide, Protein degrader building block for PROTAC research, Crosslinker−E3 Ligase ligand conjugate, Template for synthesis of targeted protein degrader, Pom

Specifiche e purezza

≥95%

Informazioni legali

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Condizioni di conservazione di stoccaggio

Store at 2-8°C

Spedito in

Wet ice

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Purezza

≥95%