Praziquantel - 10mM in DMSO , Voltage-activated calcium channel beta 2 subunit blocker, CAS No.55268-74-1, Voltage-activated calcium channel beta 2 subunit blocker

CAS: 55268-74-1 Cat. No.: P408130 Formula: C₁₉H₂₄N₂O₂ Peso molecolare: 312.41 Beilstein Registry Number: 761557 Numero EC: 259-559-6

GRADE & PURITY 10mM in DMSO

Synonyms

2-​(cyclohexylcarbonyl)​-​1,​2,​3,​6,​7,​11b-​hexahydro-4H-​pyrazino[2,​1-​a]​isoquinolin-​4-​one

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Praziquantel is an anthelmintic effective against flatworms.
In vitro

In vivo

Cell Data

cell lines：androgen-sensitive Shionogi cell

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinonimi

2-​(cyclohexylcarbonyl)​-​1,​2,​3,​6,​7,​11b-​hexahydro-4H-​pyrazino[2,​1-​a]​isoquinolin-​4-​one

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

Praziquantel is an anthelmintic effective against flatworms.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

BLOCKER

Meccanismo d'azione

Voltage-activated calcium channel beta 2 subunit blocker

Nomi e identificatori

• Isomeri SMILES: C1CCC(CC1)C(=O)N2CC3C4=CC=CC=C4CCN3C(=O)C2
• WGK Germania: 1
• RTECS: UQ4150000
• Peso molecolare: 312.41
• Beilstein: 761557
• Reaxy-Rn: 761557
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=761557&ln=

Proprietà chimiche e fisiche

• Solubilità: Solubility (25°C) In vitro DMSO: 26 mg/mL (196.8 mM); Water: 26 mg/mL (196.8 mM); Ethanol: 26 mg/mL
• Punto di fusione (°C): 136-138°C

Riferimenti

1. Jieqing Feng, Qisheng Zhong, Ting Zhou.  (2022)  Online Pressure Change Focusing-Supercritical Fluid Selective Extraction Chromatography for Analyzing Chiral Drugs in Microliter-Scale Plasma Samples.  ANALYTICAL CHEMISTRY,      [PMID:36356211] [10.1021/acs.analchem.2c03892]

2. Xiao Tu, Chenxi Duan, Siwei Wu, Shengli Fu, Jianmin Ye.  (2021)  Identification of plumbagin as an effective chemotherapeutic agent for treatment of Gyrodactylus infections.  AQUACULTURE,      [PMID:] [10.1016/j.aquaculture.2021.736372]

3. Renjie Hui, Yueying Gao, Jingyi Liu, Haili Liu, Chunlei Tang, Bainian Feng.  (2018)  Determination of an isonicotinylhydrazide derivative, a novel positive inotropic compound, in mouse plasma by LC–MS/MS and its application to a pharmacokinetics study.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:30496986] [10.1016/j.jpba.2018.10.034]

4. Qiang LI, Yuan-Yuan LI, Nan ZHU, Zhu-Xian GAO, Tian-Jun LI, Tong ZHOU, Yu-Long MA.  (2018)  Preparation of Cyclodextrin Type Stationary Phase Based on Graphene Oxide and Its Application in Enantioseparation and Hydrophilic Interaction Chromatography.  CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,      [PMID:] [10.1016/S1872-2040(18)61111-9]

5. Xiao Tu, Jiaxin Hu, Jinghao Peng, Qihan Chen, Yangle Zhao, Zemao Gu.  (2025)  Discovery of thymoquinone analogues with high anthelmintic activity against monogenean infections in goldfish (Carassius auratus).  VETERINARY PARASITOLOGY,      [PMID:39837239] [10.1016/j.vetpar.2025.110401]

6. Jing Yuan, Wenhao Su, Jingyang Gao, Xiaoqing Ma, Ronghuan Yin, Tong Jia.  (2025)  Pluronic P123/L64 Mixed Micelles as Immediate Release Systems to Enhance the Bioavailability of Praziquantel in Rats.  International Journal of Nanomedicine,      [PMID:40657482] [10.2147/IJN.S520910]

Domande frequenti

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 55268-74-1, the molecular formula is C19H24N2O2, and the molecular weight is 312.41 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.