Probucol - Moligand™, 10mM in DMSO , ATP-binding cassette sub-family A member 1 inhibitor, CAS No.23288-49-5, ATP-binding cassette sub-family A member 1 inhibitor

CAS: 23288-49-5 Cat. No.: P408795 Formula: C₃₁H₄₈O₂S₂ Peso molecolare: 516.84 Numero EC: 245-560-9

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

DH-581 | 4,​4'-​[(1-​methylethylidene)​bis(thio)​]​bis[2,​6-​bis(1,​1-​dimethylethyl)​-phenol

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Probucol Probucol (DH-581) is an anti-hyperlipidemic drug by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinonimi

DH-581 | 4,​4'-​[(1-​methylethylidene)​bis(thio)​]​bis[2,​6-​bis(1,​1-​dimethylethyl)​-phenol

Specifiche e purezza

Moligand™, 10mM in DMSO

Meccanismi biochimici e fisiologici

Probucol (DH-581) is an anti-hyperlipidemic drug by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

INHIBITOR

Meccanismo d'azione

ATP-binding cassette sub-family A member 1 inhibitor

Proprietà del prodotto

• ALogP: 11.3

Nomi e identificatori

• Isomeri SMILES: CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)SC(C)(C)SC2=CC(=C(C(=C2)C(C)(C)C)O)C(C)(C)C
• RTECS: AL3705000
• Peso molecolare: 516.84
• Reaxy-Rn: 2026253
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2026253&ln=

Obiettivi associati (umani)

HPN Tchem Serine protease hepsin (1 Activities)

Discover Target: HPN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Proprietà chimiche e fisiche

• Solubilità: Solubility (25°C) In vitro
• Punto di fusione (°C): 128°C

Riferimenti

1. Xiaowei Wang, Wenjun Zhang, Sheng Zeng, Liudi Wang, Bin Wang.  (2023)  Collagenase Type I and Probucol-Loaded Nanoparticles Penetrate the Extracellular Matrix to Target Hepatic Stellate Cells for Hepatic Fibrosis Therapy.  Acta Biomaterialia,      [PMID:38141933] [10.1016/j.actbio.2023.12.027]

2. Hongyan Lu, Guangzhao Yang, Fu Ran, Tianbin Gao, Changshan Sun, Qinfu Zhao, Siling Wang.  (2019)  Polymer-functionalized mesoporous carbon nanoparticles on overcoming multiple barriers and improving oral bioavailability of Probucol.  CARBOHYDRATE POLYMERS,      [PMID:31826471] [10.1016/j.carbpol.2019.115508]