Propylthiouracil - Moligand™, 10mM in DMSO , CAS No.51-52-5

CAS: 51-52-5 Cat. No.: P408382 Formula: C₇H₁₀N₂OS Peso molecolare: 170.23 Beilstein Registry Number: 130039 Numero EC: 200-103-2

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

NSC 6498, NSC 70461 | 2,​3-​dihydro-​6-​propyl-​2-​thioxo-4(1H)​-​pyrimidinone

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Propylthiouracil Propylthiouracil (NSC 6498, NSC 70461) is a thyroperoxidase and 5'-deiodinase inhibitor, used to treat hyperthyroidism.
In vitro

In vivo

Propylthiouracil-induced hypothyroidism reduces oxidative damage in the lung, hepatic, renal and ileal tissues probably due to hypometabolism in rats, which is associated with decreased production of reactive oxygen metabolites and enhancement of antioxidant mechanisms. Propylthiouracil-induced congenital hypothyroidism upregulates vimentin phosphorylation and depletes antioxidant defenses in immature rat testis. Propylthiouracil results in lesser concentrations of thyroxine (T4) and triiodothyronine (T3), greater concentrations of follicle stimulating hormone (FSH) and luteinizing hormone (LH) peptides, and increase in steroidogenic gene expression after 12 hours and 48 hours in zebrafish. Propylthiouracil-induced hypothyroidism is associated with increased tolerance of the isolated rat heart toischaemia-reperfusion. Propylthiouracil (PTU) dramatically reduces thyroid hormones on PND21 and produced deficits in body weight that persisted to adulthood in developing rats. Propylthiouracil inhibits both the synthesis of thyroid hormones in the thyroid gland and the conversion of T4 to its active form, T3. Propylthiouracil treatment significantly increases circulating TSH at both P3 and P7. Propylthiouracil exposure of adult rats, at a dose inducing modest reductions in circulating T4 concentrations and no significant effect on brain BDNF, significantly alteres the thyroid hormones and hippocampal BDNF levels in the offspring at 3 and 7 d after birth.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinonimi

NSC 6498, NSC 70461 | 2,​3-​dihydro-​6-​propyl-​2-​thioxo-4(1H)​-​pyrimidinone

Specifiche e purezza

Moligand™, 10mM in DMSO

Meccanismi biochimici e fisiologici

Propylthiouracil (NSC 6498, NSC 70461) is a thyroperoxidase and 5\'-deiodinase inhibitor, used to treat hyperthyroidism.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

INHIBITOR

Nomi e identificatori

• Isomeri SMILES: CCCC1=CC(=O)NC(=S)N1
• WGK Germania: 3
• RTECS: YR1400000
• Peso molecolare: 170.23
• Beilstein: 130039
• Reaxy-Rn: 130039
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=130039&ln=

Obiettivi associati (umani)

TAS2R38 Tchem Taste receptor type 2 member 38 (0 Activities)

Discover Target: TAS2R38

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TPO Tclin Thyroid peroxidase (0 Activities)

Discover Target: TPO

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Proprietà chimiche e fisiche

• Punto di infiammabilità (°F): 300 °C
• Punto di infiammabilità (°C): 300°C
• Punto di fusione (°C): 218-221°C

Riferimenti

1. Min Li, Qingfeng He, Li Yao, Xiaofeng Wang, Zhijia Tang, Xiao Zhu, Hai-Shu Lin, Xiaoqiang Xiang.  (2021)  Simultaneous Quantification of Propylthiouracil and Its N-β-d Glucuronide by HPLC-MS/MS: Application to a Metabolic Study.  Pharmaceuticals,  14  (11): (1194).  [PMID:34832976] [10.3390/ph14111194]

2. Yuntian Xiao, Wenchao Yang, Ling Zhou, Hongxun Hao, Ying Bao, Qiuxiang Yin, Chuang Xie.  (2021)  Growth mechanism of the spherulitic propylthiouracil–kaempferol cocrystal: new perspectives into surface nucleation.  CRYSTENGCOMM,  23  (12): (2367-2375).  [PMID:] [10.1039/D1CE00022E]

3. Yongjie Zhang, Luyao Feng, Jingyan Luan, Guomei Zhang, Ning Sheng, Jinglin Shen.  (2023)  A cooperative effect of copper-induction and AIE leading to bright luminescence of gold nanoclusters.  Inorganic Chemistry Frontiers,  11  (1): (237-245).  [PMID:] [10.1039/D3QI01974H]

4. Yanmin Shen, Yu Bi, Peixia Zhao, Xiaolong Yang, Zheng Zhang, Dan Dang, Han Wang, Wenju Liu.  (2023)  Equilibrium solubility of 6-propyl-2-thiouracil in nine pure solvents: Determination, correlation, Hansen solubility parameter and thermodynamic properties.  JOURNAL OF THE INDIAN CHEMICAL SOCIETY,      [PMID:] [10.1016/j.jics.2023.100934]

5. Wenju Liu, Yanmin Shen, Fankun Zeng, Shuanghui Lu, Jun Li, Jinjin Yang, Kewen Zhang.  (2021)  Solubility Measurement and Model Correlating of 6-Propyl-2-Thiouracil in Four Binary Solvents at 278.15–323.15 K.  JOURNAL OF CHEMICAL AND ENGINEERING DATA,      [PMID:] [10.1021/acs.jced.1c00071]

Domande frequenti

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 51-52-5, the molecular formula is C7H10N2OS, and the molecular weight is 170.23 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.