Prostaglandin H2 - ≥95%, 100 μg/ml in acetone , CAS No.42935-17-1

CAS: 42935-17-1 Cat. No.: P489872 Formula: C₂₀H₃₂O₅ Peso molecolare: 352.47 PubChem CID: 445049

GRADE & PURITY ≥95%, 100 μg/ml in acetone

Synonyms

9,11-Epoxymethano-pgh2 | Endoperoxide H2

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Prostaglandin H2 (PGH2) is a very unstable compound and therefore, stock solutions should be kept on ice, at all times, while performing experiments in the lab. PGH2 is supplied as a solution in acetone. To change the solvent, first place the vial of PGH2 on ice. Next, evaporate the acetone under a gentle stream of nitrogen and immediately add the solvent of choice. PGH, is soluble in the organic solvent ethanol at a concentration of approximately 100 mg/ml.

Specifications

Sinonimi

9,11-Epoxymethano-pgh2 | Endoperoxide H2

Specifiche e purezza

≥95%, 100 μg/ml in acetone

Meccanismi biochimici e fisiologici

Major prostanoid; important precursor in eicosanoid synthesis. Formed following catalysis of arachidonic acid (AA) by COX and is subsequently converted by cell-specific synthases to form biologically active PGs and thromboxane.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Nota

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purezza

≥95%

Nomi e identificatori

Pubchem Sid

528770173

Sorrisi canonici

CCCCCC(C=CC1C2CC(C1CC=CCCCC(=O)O)OO2)O

IUPAC Name

(Z)-7-[(1R,4S,5R,6R)-6-[(E,3S)-3-hydroxyoct-1-enyl]-2,3-dioxabicyclo[2.2.1]heptan-5-yl]hept-5-enoic acid

InChIKey

YIBNHAJFJUQSRA-YNNPMVKQSA-N

INCHI

1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1

Isomeri SMILES

CCCCC[C@@H](/C=C/[C@H]1[C@H]2C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)OO2)O

CAS alternativo

42935-17-1

PubChem CID

445049

Termini MeSH

PGH(2);PGH2;Prostaglandin H2

Peso molecolare

352.47

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Classe Fatty Acyls
      • Subclass Eicosanoids

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Classe: Fatty Acyls
• Subclass: Eicosanoids
• Intermediate Tree Nodes: Not available
• Direct Parent: Prostaglandins and related compounds
• Alternative Parents: Long-chain fatty acids Hydroxy fatty acids Heterocyclic fatty acids Unsaturated fatty acids 1,2-dioxanes 1,2-dioxolanes Secondary alcohols Dialkyl peroxides Oxacyclic compounds Monocarboxylic acids and derivatives Carboxylic acids Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic heteropolycyclic compounds
• Substituents: Prostaglandin skeleton - Long-chain fatty acid - Heterocyclic fatty acid - Hydroxy fatty acid - Ortho-dioxane - Fatty acid - Unsaturated fatty acid - Ortho-dioxolane - Dialkyl peroxide - Secondary alcohol - Carboxylic acid derivative - Carboxylic acid - Oxacycle - Organoheterocyclic compound - Monocarboxylic acid or derivatives - Organic oxide - Organic oxygen compound - Hydrocarbon derivative - Alcohol - Carbonyl group - Organooxygen compound - Aliphatic heteropolycyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as prostaglandins and related compounds. These are unsaturated carboxylic acids consisting of a 20 carbon skeleton that also contains a five member ring, and are based upon the fatty acid arachidonic acid.
• External Descriptors: Prostaglandins

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Obiettivi associati (umani)

TBXA2R Tclin Thromboxane A2 receptor (0 Activities)

Discover Target: TBXA2R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Meccanismi d'azione

Proprietà chimiche e fisiche

• Solubilità: Ethanol: >100 mg/ml
• Peso molecolare: 352.500 g/mol
• XLogP3: 3.800
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 12
• Exact Mass: 352.225 Da
• Monoisotopic Mass: 352.225 Da
• Topological Polar Surface Area: 76.000 Ų
• Heavy Atom Count: 25
• Formal Charge: 0
• Complexity: 459.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 5
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 2
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 2
• Covalently-Bonded Unit Count: 1