(Rac)-Etavopivat - ≥99% , CAS No.2622070-93-1

CAS: 2622070-93-1 Cat. No.: E646466 Molecular Weight: 457.50

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

(Rac)-Etavopivat ((Rac)-FT-4202) is an isomer of Etavopivat . Etavopivat is an orally active erythrocyte pyruvate kinase-R ( PKR ) activator that can be used in studies of sickle cell disease and other haemoglobinopathies.

In Vitro

Etavopivat (20 μM, 4 h) improves haemoglobin-oxygen affinity and reduces the sickle point (PoS) in human red blood cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Etavopivat (oral gavage, 3-22 mg/kg, once daily, 5 days) causes an increase in 2,3-DPG and ATP in crab-eating monkeys at doses of 8 mg/kg and 22 mg/kg . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

(Rac)-Etavopivat ((Rac)-FT-4202) is an isomer of Etavopivat ( HY-139573 ). Etavopivat is an orally active erythrocyte pyruvate kinase-R ( PKR ) activator that can be used in studies of sickle cell disease and other haemoglobinopathies.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ACTIVATOR

Purity

≥99%

Names and Identifiers

• Molecular Weight: 457.50