(Rac)-Lanicemine - 10mM in DMSO , CAS No.61890-25-3

CAS: 61890-25-3 Cat. No.: L656557 Formula: C₁₃H₁₄N₂ Peso molecolare: 198.26

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

(Rac)-Lanicemine ((Rac)-AZD6765) is the racemate of Lanicemine. Lanicemine (AZD6765) is a low-trapping NMDA channel blocker ( K i of 0.56-2.1 μM for NMDA receptor ; IC 50 s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects

In Vivo

Lanicemine produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects .\nLanicemine (3, 10 or 30 mg/kg; intraperitoneal) not only engages brain circuits involved in the generation of gamma- electroencephalography (EEG), but also influences these networks independent of the broader systems-level disruptions typical of ketamine . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague-Dawley rats Dosage: 3, 10 or 30 mg/kg Administration: Intraperitoneal Result: Produced pronounced dose-dependent elevations in spontaneous gamma-band EEG, but only gamma changes for Ketamine were tightly coupled to increases in locomotor activity.

IC50& Target:NMDA receptor

Specifications

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

(Rac)-Lanicemine ((Rac)-AZD6765) is the racemate of Lanicemine. Lanicemine (AZD6765) is a low-trapping NMDA channel blocker ( K i of 0.56-2.1u2009μM for NMDA receptor ; IC 50 s of 4-7u2009μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antid

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

ANTAGONIST

Nomi e identificatori

Peso molecolare

198.26