Ranolazine 2HCl - 10mM in DMSO , CAS No.95635-56-6

CAS: 95635-56-6 Cat. No.: R408393 Formula: C₂₄H₃₃N₃O₄·2HCl Peso molecolare: 500.46 Numero EC: 815-607-3 PubChem CID: 71279

GRADE & PURITY 10mM in DMSO

Synonyms

RS-43285 | N-(2,6-dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)piperazin-1-yl)acetamide dihydrochloride

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Ranolazine 2HCl Ranolazine 2HCl (RS-43285) is a calcium uptake inhibitor via the sodium/calcium channal , used to treat chronic angina.
In vitro

Ranolazine\xa0selectively inhibits\xa0late\xa0I(Na), reduces [Na(+)](i)-dependent calcium overload and attenuates the abnormalities of ventricular repolarisation and contractility that are associated with ischaemia/reperfusion and heart failure in myocardial cells. Ranolazine\xa0significantly and reversibly shortens the action potential duration (APD) of\xa0myocytes\xa0stimulated at either 0.5 Hz or 0.25 Hz in a concentration-dependent manner in left ventricular myocytes of dogs.\xa0Ranolazine\xa0at 5 and 10 mM reversibly shortens the duration of twitch\xa0contractions\xa0(TC) and abolished the after\xa0contraction. Ranolazine\xa0is found to bind more tightly to the inactivated state than the resting state of the\xa0sodium\xa0channel underlying I(NaL).

In vivo

Ranolazine\xa0(10 mM) significantly increases\xa0glucose\xa0oxidation\xa01.5-fold to 3-fold under conditions in which the contribution of\xa0glucoseto overall ATP production is low (low Ca, high FA, with insulin), high (high Ca, low Fa, with pacing), or intermediate in working\xa0hearts. Ranolazine\xa0similarly increases glucose\xa0oxidation in\xa0normoxic\xa0Langendorff\xa0hearts\xa0(high Ca, low FA; 15 mL/min). Ranolazine\xa0also significantly increases it during flow reduction to 7 mL/min, 3 mL/min, and 0.5 mL/min. Ranolazine\xa0significantly improves functional outcome, which is associated with significant increases in\xa0glucoseoxidation, a reversal of the increased FA\xa0oxidation\xa0seen in control reperfusions (versus preischemic), and a smaller but significant increase in glycolysis in\xa0reperfuse dischemic\xa0working\xa0hearts.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinonimi

RS-43285 | N-(2,6-dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)piperazin-1-yl)acetamide dihydrochloride

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

Ranolazine 2HCl (RS-43285) is a calcium uptake inhibitor via the sodium/calcium channal, used to treat chronic angina.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Nomi e identificatori

Isomeri SMILES

CC1=C(C(=CC=C1)C)NC(=O)CN2CCN(CC2)CC(COC3=CC=CC=C3OC)O.Cl.Cl

WGK Germania

3

PubChem CID

71279

Peso molecolare

500.46

Proprietà chimiche e fisiche

• Punto di fusione (°C): 222-229.5°C

Domande frequenti

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 95635-56-6, the molecular formula is C24H33N3O4·2HCl, and the molecular weight is 500.46 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.