Razuprotafib - Moligand™, 10 mM in DMSO , CAS No.1008510-37-9

CAS: 1008510-37-9 Cat. No.: R1494230 Formula: C₂₆H₂₆N₄O₆S₃ Peso molecolare: 586.7 PubChem CID: 46700782

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Razuprotafib (AKB-9778) is a potent and selective inhibitor of the catalytic activity of VE-PTP (vascular endothelial protein tyrosine phosphatase ) with an IC 50 of 17 pM. Razuprotafib promotes TIE2 activation, enhances ANG1-induced TIE2 activation, and stimulates phosphorylation of signaling molecules in the TIE2 pathway, including AKT , eNOS , and ERK . Razuprotafib inhibits the structurally related phosphatase PTP1B with an IC 50 of 780 nM. Razuprotafib shows excellent selectivity for VE-PTP versus a variety of phosphatases, with the exception of HPTPη (IC 50 =36 pM) and HPTPγ (100 pM).

Specifications

Specifiche e purezza

Moligand™, 10 mM in DMSO

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

INHIBITOR

Proprietà del prodotto

• ALogP: 3.7

Nomi e identificatori

• Isomeri SMILES: COC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC2=CC=C(C=C2)NS(=O)(=O)O)C3=CSC(=N3)C4=CC=CS4
• PubChem CID: 46700782
• Peso molecolare: 586.7