Rbin-1 - 10mM in DMSO , CAS No.328023-11-6

CAS: 328023-11-6 Cat. No.: R423344 Formula: C₁₃H₁₂N₄S Peso molecolare: 256.33 PubChem CID: 5731061

QUALITÀ & PUREZZA 10mM in DMSO

Synonyms

Rbin-1|Ribozinoindole-1|Butane,3-dibromo-, (R*,S*)-|Cambridge id 6586001|3-[(2-methyl-2-propenyl)sulfanyl]-5H-[1,2,4]triazino[5,6-b]indole|NITROINDAZOLE, 5-|3-((2-methylallyl)thio)-5H-[1,2,4]triazino[5,6-b]indole|3-[(2-methylprop-2-en-1-yl)sulfanyl]-5H-[1,2,4]triazino[5,6-b]indole|3-[(2-methylprop-2-en-1-yl)thio]-5H-[1,2,4]triazino[5,6-b]indole|3-(2-Methylallylthio)-5H-[1,2,4]triazino[5,6-b]indole|3-[(2-Methyl-2-propen-1-yl)thio]-5H-1,2,4-triazino[5,6-b]indole|3-(2-methylprop-2-enylsulfanyl)-5H-[1,2,4]triazino[5,6-b]indole

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Rbin-1 Rbin-1 (Ribozinoindole-1) is a potent chemical inhibitor of eukaryotic ribosome assembly . It inhibits recombinant full-length Mdn1's ATPase activity in vitro.

Targets

Mdn1

In vitro

Ribozinoindoles are potent chemical inhibitors of eukaryotic ribosome assembly. Rbin-1 targets Mdn1 or cellular processes that involve this protein. It efficiently inhibit the growth of yeast cells.

Specifiche

Sinonimi

Rbin-1 | Ribozinoindole-1 | Butane,3-dibromo-, (R*,S*)- | Cambridge id 6586001 | 3-[(2-methyl-2-propenyl)sulfanyl]-5H-[1,2,4]triazino[5,6-b]indole | NITROINDAZOLE, 5- | 3-((2-methylallyl)thio)-5H-[1,2,4]triazino[5,6-b]indole | 3-[(2-methylprop-2-en-1-yl)sulfanyl]-5H-[1,2,4]triazino[5,6-b]indole | 3-[(2-methylprop-2-en-1-yl)thio]-5H-[1,2,4 Mostra altro

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

Rbin-1 (Ribozinoindole-1) is a potent chemical inhibitor of eukaryotic ribosome assembly. It inhibits recombinant full-length Mdn1's ATPase activity in vitro.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Proprietà del prodotto

ALogP

3.83

Conteggio HBD

1

Legame rotabile

3

Nomi e identificatori

Pubchem Sid

528766933

Sorrisi canonici

CC(=C)CSC1=NC2=C(C3=CC=CC=C3N2)N=N1

IUPAC Name

3-(2-methylprop-2-enylsulfanyl)-5H-[1,2,4]triazino[5,6-b]indole

InChIKey

LPCWHNSRTRBKBO-UHFFFAOYSA-N

INCHI

1S/C13H12N4S/c1-8(2)7-18-13-15-12-11(16-17-13)9-5-3-4-6-10(9)14-12/h3-6H,1,7H2,2H3,(H,14,15,17)

Isomeri SMILES

CC(=C)CSC1=NC2=C(C3=CC=CC=C3N2)N=N1

PubChem CID

5731061

Peso molecolare

256.33

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Indoles and derivatives
      • Subclass Indoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Indoles and derivatives
• Subclass: Indoles
• Intermediate Tree Nodes: Not available
• Direct Parent: Indoles
• Alternative Parents: Alkylarylthioethers Benzenoids 1,2,4-triazines Pyrroles Heteroaromatic compounds Sulfenyl compounds Azacyclic compounds Organonitrogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Indole - Aryl thioether - Alkylarylthioether - Triazine - Benzenoid - 1,2,4-triazine - Pyrrole - Heteroaromatic compound - Sulfenyl compound - Thioether - Azacycle - Hydrocarbon derivative - Organosulfur compound - Organonitrogen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as indoles. These are compounds containing an indole moiety, which consists of pyrrole ring fused to benzene to form 2,3-benzopyrrole.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Meccanismi d'azione

Proprietà chimiche e fisiche

• DMSO (mg/mL) Solubilità massima: 23
• DMSO (mM) Solubilità massima: 89.72808489
• Acqua (mg/mL) Solubilità massima: ＜1
• Peso molecolare: 256.329 g/mol
• XLogP3: 3.200
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 256.078 Da
• Monoisotopic Mass: 256.078 Da
• Topological Polar Surface Area: 79.800 Ų
• Heavy Atom Count: 18
• Formal Charge: 0
• Complexity: 322.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1