Resolvin D1 - Moligand™, ≥95%, A solution in ethanol , Agonist of FPR2/ALX;Agonist of GPR32;Gating inhibitor of TRPA1, CAS No.872993-05-0, Agonist of FPR2/ALX;Agonist of GPR32;Gating inhibitor of TRPA1

CAS: 872993-05-0 Cat. No.: R341442 Formula: C₂₂H₃₂O₅ Peso molecolare: 376.5 PubChem CID: 53394122

GRADE & PURITY Moligand™, ≥95%, A solution in ethanol

Synonyms

17(R)-Resolvin D1 | SB48260 | RvD1 | Resolvin D1 | 7,8,17-TRIHYDROXYDOCOSA-4,9,11,13,15,19-HEXAENOIC ACID | 17(R)-RvD1 | DTXSID60694000

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Resolvin D1 is from a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA) and docosahexaenoic (DHA)(1), it is an anti-inflammatory and promotes the resolution of the inflammatory response back to a non-inflamed state.2 RvD1 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase. It reduces human polymorphonuclear leukocyte (PMNL) transendothelial migration, the earliest event in acute inflammation, with EC50 values of ~30 nM. It exhibits a dose-dependent reduction in leukocyte infiltration in a murine model of peritonitis with a maximal inhibition of ~35% at a 10-100 ng dose.

Resolvin D1 (RvD1) is supplied as a solution in ethanol. To change the solvent, simply evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice. It is recommended that this product be stored and handled in an ethanol solution. Resolvins can isomerize and degrade when put into freeze thaw conditions and/or in solvents such as dimethyl formamide or DMSO.

Specifications

Sinonimi

17(R)-Resolvin D1 | SB48260 | RvD1 | Resolvin D1 | 7,8,17-TRIHYDROXYDOCOSA-4,9,11,13,15,19-HEXAENOIC ACID | 17(R)-RvD1 | DTXSID60694000

Specifiche e purezza

Moligand™, ≥95%, A solution in ethanol

Condizioni di conservazione di stoccaggio

Protected from light,Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

AGONIST, GATING INHIBITOR

Meccanismo d'azione

Agonist of FPR2/ALX;Agonist of GPR32;Gating inhibitor of TRPA1

Purezza

≥95%

Nomi e identificatori

Sorrisi canonici

CCC=CCC(C=CC=CC=CC=CC(C(CC=CCCC(=O)O)O)O)O

IUPAC Name

7,8,17-trihydroxydocosa-4,9,11,13,15,19-hexaenoic acid

InChIKey

OIWTWACQMDFHJG-UHFFFAOYSA-N

INCHI

1S/C22H32O5/c1-2-3-9-14-19(23)15-10-6-4-5-7-11-16-20(24)21(25)17-12-8-13-18-22(26)27/h3-12,15-16,19-21,23-25H,2,13-14,17-18H2,1H3,(H,26,27)

Isomeri SMILES

CCC=CCC(C=CC=CC=CC=CC(C(CC=CCCC(=O)O)O)O)O

PubChem CID

53394122

Peso molecolare

376.5

Obiettivi associati (umani)

GPR32 Tchem Probable G-protein coupled receptor 32 (1 Activities)

Discover Target: GPR32

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FPR2 Tchem N-formyl peptide receptor 2 (1 Activities)

Discover Target: FPR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPA1 Tclin Transient receptor potential cation channel subfamily A member 1 (1 Activities)

Discover Target: TRPA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Proprietà chimiche e fisiche

• Solubilità: Soluble in water (0.05 mg/mL) at 25° C, PBS pH 7.2 (~0.05 mg/mL), DMSO (~50 mg/mL), DMF (~50 mg/mL), and ethanol.
• Sensibilità: Light sensitive
• Punto di ebollizione (°C): 78° C

Domande frequenti

What is the purity of this product?

This product is supplied at ≥95% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C, protected from light. The material is light-sensitive — keep it in its original opaque or amber container.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 872993-05-0, the molecular formula is C22H32O5, and the molecular weight is 376.5 g/mol. InChIKey OIWTWACQMDFHJG-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.