Rhodionin - Moligand™, ≥98% , CAS No.85571-15-9

CAS: 85571-15-9 Cat. No.: R649847 Formula: C₂₁H₂₀O₁₁ Peso molecolare: 448.38 Numero EC: 875-666-6 PubChem CID: 21626477

GRADE & PURITY Moligand™, ≥98%

Synonyms

AKOS030530360 | MFCD13195580 | UNII-889FQ29409 | Q-100861 | HERBACETIN 7-O-.ALPHA.-L-RHAMNOPYRANOSIDE | 889FQ29409 | 4H-1-Benzopyran-4-one, 7-((6-deoxy-alpha-L-mannopyranosyl)oxy)-3,5,8-trihydroxy-2-(4-hydroxyphenyl)- | AC-34095 | Herbacetin 7-o-alpha-L-r

Storage

Protected from light,Store at -20°C,Argon charged,Desiccated

Shipped In

Ice chest + Ice pads

Panoramica

Rhodionin, isolated from the root of Rhodiola crenulata , is a specific non-competitive cytochrome P450 2D6 inhibitor with an IC 50 of 0.761 μM and a Ki of 0.769 μM Rhodionin exhibits potent, dose-dependent inhibitory effects on acetylcholinesterase (AChE) with IC 50 ranged from 57.50 to 2.43 μg/mL Rhodionin exhibits potent DPPH free radical scavenging activities, with an IC 50 of 19.49 μM

Form:Solid

IC50& Target:AChE

Specifications

Sinonimi

AKOS030530360 | MFCD13195580 | UNII-889FQ29409 | Q-100861 | HERBACETIN 7-O-.ALPHA.-L-RHAMNOPYRANOSIDE | 889FQ29409 | 4H-1-Benzopyran-4-one, 7-((6-deoxy-alpha-L-mannopyranosyl)oxy)-3,5,8-trihydroxy-2-(4-hydroxyphenyl)- | AC-34095 | Herbacetin 7-o-alpha-L-r

Specifiche e purezza

Moligand™, ≥98%

Meccanismi biochimici e fisiologici

Rhodionin, isolated from the root of Rhodiola crenulata , is a specific non-competitive cytochrome P450 2D6 inhibitor with an IC 50 of 0.761 μM and a Ki of 0.769 μM. Rhodionin exhibits potent, dose-dependent inhibitory effects on acetylcholinesterase

Condizioni di conservazione di stoccaggio

Protected from light,Store at -20°C,Argon charged,Desiccated

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

INHIBITOR

Purezza

≥98%

Nomi e identificatori

Sorrisi canonici

CC1C(C(C(C(O1)OC2=C(C3=C(C(=C2)O)C(=O)C(=C(O3)C4=CC=C(C=C4)O)O)O)O)O)O

IUPAC Name

3,5,8-trihydroxy-2-(4-hydroxyphenyl)-7-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one

InChIKey

CIAXXTSXVCLEJK-JOEVVYSCSA-N

INCHI

1S/C21H20O11/c1-7-13(24)16(27)18(29)21(30-7)31-11-6-10(23)12-15(26)17(28)19(32-20(12)14(11)25)8-2-4-9(22)5-3-8/h2-7,13,16,18,21-25,27-29H,1H3/t7-,13-,16+,18+,21-/m0/s1

Isomeri SMILES

C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC2=C(C3=C(C(=C2)O)C(=O)C(=C(O3)C4=CC=C(C=C4)O)O)O)O)O)O

CAS alternativo

85571-15-9

PubChem CID

21626477

Termini MeSH

herbacetin 7-O-rhamnopyranoside;rhodionin

Peso molecolare

448.38

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Phenylpropanoids and polyketides
    • Classe Flavonoids
      • Subclass Flavonoid glycosides
        • Level5 Flavonoid O-glycosides
          • Level6 Flavonoid-7-O-glycosides

• Kingdom: Organic compounds
• Superclass: Phenylpropanoids and polyketides
• Classe: Flavonoids
• Subclass: Flavonoid glycosides
• Intermediate Tree Nodes: Flavonoid O-glycosides
• Direct Parent: Flavonoid-7-O-glycosides
• Alternative Parents: Flavonols 3-hydroxyflavonoids 4'-hydroxyflavonoids 5-hydroxyflavonoids 8-hydroxyflavonoids Phenolic glycosides Hexoses Chromones O-glycosyl compounds 1-hydroxy-2-unsubstituted benzenoids Pyranones and derivatives Oxanes Benzene and substituted derivatives Vinylogous acids Heteroaromatic compounds Secondary alcohols Acetals Oxacyclic compounds Polyols Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Flavonoid-7-o-glycoside - 3-hydroxyflavone - Hydroxyflavonoid - 3-hydroxyflavonoid - Flavone - 8-hydroxyflavonoid - 5-hydroxyflavonoid - 4'-hydroxyflavonoid - Phenolic glycoside - Hexose monosaccharide - O-glycosyl compound - Chromone - Glycosyl compound - 1-benzopyran - Benzopyran - Phenol - 1-hydroxy-2-unsubstituted benzenoid - Pyranone - Monocyclic benzene moiety - Benzenoid - Pyran - Monosaccharide - Oxane - Vinylogous acid - Heteroaromatic compound - Secondary alcohol - Organoheterocyclic compound - Oxacycle - Polyol - Acetal - Organic oxide - Organic oxygen compound - Alcohol - Hydrocarbon derivative - Organooxygen compound - Aromatic heteropolycyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as flavonoid-7-o-glycosides. These are phenolic compounds containing a flavonoid moiety which is O-glycosidically linked to carbohydrate moiety at the C7-position.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Meccanismi d'azione

Proprietà chimiche e fisiche

• Solubilità: DMSO : 16.67 mg/mL (37.18 mM; Need ultrasonic)
• Peso molecolare: 448.400 g/mol
• XLogP3: 0.900
• Hydrogen Bond Donor Count: 7
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 3
• Exact Mass: 448.101 Da
• Monoisotopic Mass: 448.101 Da
• Topological Polar Surface Area: 186.000 Ų
• Heavy Atom Count: 32
• Formal Charge: 0
• Complexity: 733.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 5
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1