Rifaximin - Moligand™, 10mM in DMSO , CAS No.80621-81-4

CAS: 80621-81-4 Cat. No.: R408980 Formula: C₄₃H₅₁N₃O₁₁ Peso molecolare: 785.88 Numero EC: 617-130-4 PubChem CID: 6436173

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

(2S,​16Z,​18E,​20S,​21S,​22R,​23R,​24R,​25S,​26R,​27S,​28E)​-25-​(acetyloxy)​-​5,​6,​21,​23-​tetrahydroxy-​27-​methoxy-​2,​4,​11,​16,​20,​22,​24,​26-​octamethyl-​2,​7-​(Epoxypentadeca[1,​11,​13]​trienimino)​benzofuro[4,​5-​e]​pyrido[1,​2-​a]​benzimidazole

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Rifaximin Rifaximin is a RNA synthesis inhibitor by binding the β subunit of the bacterial DNA-dependent RNA polymerase, used to treat traveler's diarrhea caused by certain bacteria.
In vitro

Rifaximin (50 μM) reduces changes in the production of proinflammatory factors caused by LPS stimulation in IEC, such as TNF-α, IL-8, Rantes and PGE2 in normal intestinal epithelial cells. Rifaximin inhibits the LPS-induced cytokine and chemokine expression by suppressing NF-κB DNA-binding activity. Rifaximin (100 μM) effectively decreases the expression of TNFα, IL-8, MIP-3α and Rantes induced by LPS stimulation (100 μg/mL). Rifaximin binds the β subunit of the bacterial DNA-dependent RNA polymerase, inhibiting the initiation of chain formation in RNA synthesis. Rifaximin has a lower MIC against gram-positive bacteria, with an MIC90 at dosages ranging from 0.01 µg/mL to 0.5 µg/mL. Rifaximin has broad-spectrum activity against aerobic and anaerobic gram-positive and gram-negative microorganisms.

In vivo

Rifaximin is highly concentrated in the intestinal tract compared with rifampicin. Rifaximin treatment results in significant induction of PXR target genes in the intestine of hPXR mice, but not in wild-type and Pxr- mice. Rifaximin-mediated activation of human PXR, but not the other xenobiotic nuclear receptors constitutive androstane receptor, peroxisome proliferator-activated receptor (PPAR)alpha, PPARgamma, and farnesoid X receptor. Rifaximin could lead to PXR-dependent hepatocellular fatty degeneration as a result of activation of genes involved in lipid uptake, thus indicating a potential adverse effect of rifaximin on liver function after long-term exposure.
Cell Data

cell lines：NCI-H441 cells

Concentrations：

Incubation Time：

Powder Purity:≥97%

Specifications

Sinonimi

(2S,​16Z,​18E,​20S,​21S,​22R,​23R,​24R,​25S,​26R,​27S,​28E)​-25-​(acetyloxy)​-​5,​6,​21,​23-​tetrahydroxy-​27-​methoxy-​2,​4,​11,​16,​20,​22,​24,​26-​octamethyl-​2,​7-​(Epoxypentadeca[1,​11,​13]​trienimino)​benzofuro[4,​5-​e]​pyrido[1,​2-​a]​benzimidazole

Specifiche e purezza

Moligand™, 10mM in DMSO

Meccanismi biochimici e fisiologici

Rifaximin is a RNA synthesis inhibitor by binding the β subunit of the bacterial DNA-dependent RNA polymerase, used to treat traveler\'s diarrhea caused by certain bacteria.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Proprietà del prodotto

ALogP

6.9

Nomi e identificatori

Isomeri SMILES

C[C@H]1/C=C/C=C(\C(=O)NC2=C(C3=C(C4=C(C(=C3O)C)O[C@@](C4=O)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)C5=C2N6C=CC(=CC6=N5)C)O)/C

PubChem CID

6436173

Peso molecolare

785.88

Proprietà chimiche e fisiche

• Punto di fusione (°C): 212 °C

Domande frequenti

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 80621-81-4, the molecular formula is C43H51N3O11, and the molecular weight is 785.88 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.