Rigosertib sodium - Moligand™, ≥97% , CAS No.592542-60-4

Name: Rigosertib sodium - Moligand™, ≥97% , CAS No.592542-60-4
Brand: Aladdin Scientific
SKU: R647117
Availability: InStock

CAS: 592542-60-4 Cat. No.: R647117 Molecular Weight: 473.47

COA

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Rigosertib sodium - Moligand™, ≥97% CAS No(592542-60-4) by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY Moligand™ ? ≥97%

Synonyms

ON-01910Na | ON-019190 (sodium) | rigosertib sodium salt | ON 01910.Na | SODIUM 2-[(2-METHOXY-5-{[2-(2,4,6-TRIMETHOXYPHENYL)ETHENESULFONYL]METHYL}PHENYL)AMINO]ACETATE | Glycine, N-[2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]phen

Storage

Store at 2-8°C,Protected from light,Argon charged

Shipped In

Wet ice

Overview Specifications Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solution Calculators Reviews

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Why this grade

Moligand™, ≥97% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at 2-8°C,Protected from light,Argon charged Ships Wet ice Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Rigosertib sodium (ON-01910), a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.

Specifications

Synonyms

ON-01910Na | ON-019190 (sodium) | rigosertib sodium salt | ON 01910.Na | SODIUM 2-[(2-METHOXY-5-{[2-(2, 4, 6-TRIMETHOXYPHENYL)ETHENESULFONYL]METHYL}PHENYL)AMINO]ACETATE | Glycine, N-[2-Methoxy-5-[[[(1E)-2-(2, 4, 6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]phen

Specifications & Purity

Moligand™, ≥97%

Biochemical and Physiological Mechanisms

Rigosertib sodium (ON-01910 sodium) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3K/Akt pathway, promotes the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle.

Storage

Store at 2-8°C, Protected from light, Argon charged

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Purity

≥97%

Names and Identifiers

Pubchem Sid	528766955
Canonical Smiles	COC1=C(C=C(C=C1)CS(=O)(=O)C=CC2=C(C=C(C=C2OC)OC)OC)NCC(=O)[O-].[Na+]
IUPAC Name	sodium;2-[2-methoxy-5-[[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonylmethyl]anilino]acetate
InChIKey	VLQLUZFVFXYXQE-USRGLUTNSA-M
INCHI	1S/C21H25NO8S.Na/c1-27-15-10-19(29-3)16(20(11-15)30-4)7-8-31(25,26)13-14-5-6-18(28-2)17(9-14)22-12-21(23)24;/h5-11,22H,12-13H2,1-4H3,(H,23,24);/q;+1/p-1/b8-7+;
Isomeric SMILES	COC1=C(C=C(C=C1)CS(=O)(=O)/C=C/C2=C(C=C(C=C2OC)OC)OC)NCC(=O)[O-].[Na+]
Alternate CAS	592542-60-4
MeSH Entry Terms	(N-(2-methyloxy-5-(2',4',6'-trimethoxystyrylsulfonyl)methylenephenyl)amino)acetic acid;N-(2-Methoxy-5-((((E)-2-(2,4,6-trimethoxyphenyl)vinyl)sulfonyl)methyl)phenyl)glycine;ON 01910;ON 01910.Na;ON-01910;ON01910;rigosertib;rigosertib sodium;sodium (N-(2-met
Molecular Weight	473.47
Reaxy-Rn	26934487
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=26934487&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic acids and derivatives
  - Class Carboxylic acids and derivatives
    - Subclass Amino acids, peptides, and analogues
      - Level5 Amino acids and derivatives
        Level6 Alpha amino acids and derivatives
        Level7 Alpha amino acids

Kingdom	Organic compounds
Superclass	Organic acids and derivatives
Class	Carboxylic acids and derivatives
Subclass	Amino acids, peptides, and analogues
Intermediate Tree Nodes	Amino acids and derivatives - Alpha amino acids and derivatives
Direct Parent	Alpha amino acids
Alternative Parents	Aminophenyl ethers Methoxyanilines Styrenes Phenylalkylamines Phenoxy compounds Anisoles Methoxybenzenes Secondary alkylarylamines Alkyl aryl ethers Sulfones Amino acids Carboxylic acid salts Carboxylic acids Monocarboxylic acids and derivatives Hydrocarbon derivatives Organopnictogen compounds Carbonyl compounds Organic sodium salts Organic zwitterions Organic oxides
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	Alpha-amino acid - Methoxyaniline - Aminophenyl ether - Styrene - Aniline or substituted anilines - Phenylalkylamine - Phenol ether - Methoxybenzene - Anisole - Phenoxy compound - Alkyl aryl ether - Secondary aliphatic/aromatic amine - Monocyclic benzene moiety - Benzenoid - Sulfonyl - Sulfone - Carboxylic acid salt - Amino acid - Carboxylic acid - Ether - Monocarboxylic acid or derivatives - Organic alkali metal salt - Secondary amine - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Amine - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Carbonyl group - Organic oxide - Organopnictogen compound - Organic sodium salt - Organic salt - Organic zwitterion - Aromatic homomonocyclic compound
Description	This compound belongs to the class of organic compounds known as alpha amino acids. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon).
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

PLK1 Tchem Serine/threonine-protein kinase PLK1 (28605 Activities)

Discover Target: PLK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AGS (1999 Activities)

Lot Number	Certificate Type	Date	Item
C2505562	Certificate of Analysis	Oct 24, 2024	R647117
C2505563	Certificate of Analysis	Oct 24, 2024	R647117
C2505564	Certificate of Analysis	Oct 24, 2024	R647117
C2505565	Certificate of Analysis	Oct 24, 2024	R647117
C2505566	Certificate of Analysis	Oct 24, 2024	R647117
C2505567	Certificate of Analysis	Oct 24, 2024	R647117
C2505569	Certificate of Analysis	Oct 24, 2024	R647117

Solubility	DMSO : 150 mg/mL (316.81 mM; Need ultrasonic) H2O : ≥ 52 mg/mL (109.83 mM)
Sensitivity	Light sensitive
Molecular Weight	473.500 g/mol
XLogP3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	11
Exact Mass	473.112 Da
Monoisotopic Mass	473.112 Da
Topological Polar Surface Area	132.000 Å²
Heavy Atom Count	32
Formal Charge	0
Complexity	684.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	1
Covalently-Bonded Unit Count	2

Rigosertib sodium - Moligand™, ≥97% , CAS No.592542-60-4

Why this grade

Storage & shipping

Quality documents

Literature proof

Overview

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Customer Reviews

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