Rineterkib hydrochloride - ≥99% , CAS No.1715025-34-5

CAS: 1715025-34-5 Cat. No.: R646828 PubChem CID: 154572843

GRADE & PURITY ≥99%

Synonyms

Rineterkib hydrochloride | 4-[3-amino-6-[(1S,3S,4S)-3-fluoro-4-hydroxycyclohexyl]pyrazin-2-yl]-N-[(1S)-1-(3-bromo-5-fluorophenyl)-2-(methylamino)ethyl]-2-fluorobenzamide;hydrochloride | 1715025-34-5 | Benzamide, 4-(3-amino-6-((1S,3S,4S)-3-fluoro-4-hydroxy

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

Overview

Rineterkib hydrochloride (compound B) is an orally available ERK1 and ERK2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway. The activity is particularly related to the treatment of KRAS-mutant NSCLC, BRAF-mutant NSCLC, KRAS-mutant pancreatic cancer , KRAS-mutant colorectal cancer (CRC) and KRAS-mutant ovarian cancer. Rineterkib hydrochloride can also inhibit RAF.

In Vivo

ERK-IN-1 (compound B) (50, 75 mg/kg, p.o., qd/q2d, 27 days) treatment significantly reduces the tumor volume in the Calu-6 human NSCLC subcutaneous tumor xenograft model in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Calu-6 NSCLC xenograft tumor models in mice . Dosage: 50, 75 mg/kg. Administration: Orally either daily (qd) or every other day (q2d) for 27 days. Result: Significantly reduced the tumor volume.

Form:Solid

Specifications

Synonyms

Rineterkib hydrochloride | 4-[3-amino-6-[(1S, 3S, 4S)-3-fluoro-4-hydroxycyclohexyl]pyrazin-2-yl]-N-[(1S)-1-(3-bromo-5-fluorophenyl)-2-(methylamino)ethyl]-2-fluorobenzamide;hydrochloride | 1715025-34-5 | Benzamide, 4-(3-amino-6-((1S, 3S, 4S)-3-fluoro-4-hydroxy

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

Rineterkib hydrochloride (compound B) is an orally available ERK1 and ERK2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway. The activity is particularly related to the treatment of KRAS-mutan

Storage

Store at 2-8°C, Protected from light, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Names and Identifiers

• Canonical Smiles: CNCC(C1=CC(=CC(=C1)Br)F)NC(=O)C2=C(C=C(C=C2)C3=NC(=CN=C3N)C4CCC(C(C4)F)O)F.Cl
• IUPAC Name: 4-[3-amino-6-[(1S,3S,4S)-3-fluoro-4-hydroxycyclohexyl]pyrazin-2-yl]-N-[(1S)-1-(3-bromo-5-fluorophenyl)-2-(methylamino)ethyl]-2-fluorobenzamide;hydrochloride
• InChIKey: BTUJMQIKTCOSFK-XKNHYIDFSA-N
• INCHI: 1S/C26H27BrF3N5O2.ClH/c1-32-11-21(15-6-16(27)10-17(28)7-15)35-26(37)18-4-2-14(9-19(18)29)24-25(31)33-12-22(34-24)13-3-5-23(36)20(30)8-13;/h2,4,6-7,9-10,12-13,20-21,23,32,36H,3,5,8,11H2,1H3,(H2,31,33)(H,35,37);1H/t13-,20-,21+,23-;/m0./s1
• Isomeric SMILES: CNC[C@H](C1=CC(=CC(=C1)Br)F)NC(=O)C2=C(C=C(C=C2)C3=NC(=CN=C3N)[C@H]4CC[C@@H]([C@H](C4)F)O)F.Cl
• Alternate CAS: 1715025-34-5
• PubChem CID: 154572843

Chemical and Physical Properties

• Solubility: DMSO : 220 mg/mL (Need ultrasonic)