RK-33 - 10mM in DMSO , CAS No.1070773-09-9

CAS: 1070773-09-9 Cat. No.: R408134 Formula: C₂₃H₂₀N₆O₃ Peso molecolare: 428.44 PubChem CID: 46184988

GRADE & PURITY 10mM in DMSO

Synonyms

2H-​Diimidazo[4,​5-​d:4',​5'-​f]​[1,​3]​diazepin-​2-​one, 3,​7-​dihydro-​3,​7-​bis[(4-​methoxyphenyl)​methyl]​-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

RK-33 RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.
In vitro

RK-33 binds specifically to DDX3, but not to the closely related proteins DDX5 and DDX17. RK-33 inhibits cancer growth and radiosensitizes lung cancer cells in a DDX3-dependent manner. RK-33 has no effect on either mitochondrial respiration or ATP generation. RK-33 curbs proliferation and induces apoptosis in a DDX3-dependent fashion. Wnt signaling is mediated by DDX3 and inhibited by RK-33. RK-33 impairs radiation-induced DNA damage repair by inhibiting NHEJ activity.

In vivo

RK-33 in combination with radiation induces tumor regression in multiple mouse models of lung cancer. RK-33, at the dose used, is non-toxic in SCID mice. RK-33-treated mice do not exhibit any discernable morphological changes.
Cell Data

cell lines：

Concentrations：7.5 μM

Incubation Time：12 h

Powder Purity:≥99%

Specifications

Sinonimi

2H-​Diimidazo[4,​5-​d:4',​5'-​f]​[1,​3]​diazepin-​2-​one, 3,​7-​dihydro-​3,​7-​bis[(4-​methoxyphenyl)​methyl]​-

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Proprietà del prodotto

• ALogP: 2.687
• Legame rotabile: 6

Nomi e identificatori

• Isomeri SMILES: COC1=CC=C(C=C1)CN2C=NC3=C2N=CN=C4C3=NC(=O)N4CC5=CC=C(C=C5)OC
• PubChem CID: 46184988
• Peso molecolare: 428.44

Proprietà chimiche e fisiche

• DMSO (mg/mL) Solubilità massima: 85
• DMSO (mM) Solubilità massima: 198.3941742
• Acqua (mg/mL) Solubilità massima: ＜1

Domande frequenti

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1070773-09-9, the molecular formula is C23H20N6O3, and the molecular weight is 428.44 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.