Roflumilast-d4N-Oxide - ≥98% , CAS No.1794760-31-8

CAS: 1794760-31-8 Cat. No.: R651895 Formula: C₁₇H₁₀D₄Cl₂F₂N₂O₄ Peso molecolare: 423.23

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Panoramica

Roflumilast-d 4 N-Oxide is the deuterium labeled Roflumilast. Roflumilast is a selective PDE4 inhibitor with IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1 , PDE2 , PDE3 or PDE5 isoenzymes from various cells.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

Specifications

Specifiche e purezza

≥98%

Meccanismi biochimici e fisiologici

Roflumilast-d 4 N-Oxide is the deuterium labeled Roflumilast. Roflumilast is a selective PDE4 inhibitor with IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1 , PDE2 , PDE3 or PDE5 isoenzymes from

Condizioni di conservazione di stoccaggio

Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Purezza

≥98%

Nomi e identificatori

• Sorrisi canonici: [2H]C1([2H])C([2H])([2H])C1COC2=C(C=CC(C(NC3=C(Cl)C=[N+]([O-])C=C3Cl)=O)=C2)OC(F)F
• Peso molecolare: 423.23