GRADE & PURITYMoligand™?Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.10mM in DMSO
Moligand™,10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
RP 70676 is a potent inhibitor of ACAT , with IC 50 of 25 and 44 nM for rat and rabbit ACAT .
In Vitro
RP 70676 is a potent inhibitor of rabbit arterial ACAT (IC 50 = 40 nM) and has been shown to be an effective inhibitor of ACAT derived from a number of tissues and species including man. The IC 50 values range from 21 nM for hamster liver ACAT to 108 nM for enzyme from the intestine of cholesterol fed rabbits; in human hepatic tissues the mean IC 50 is 44 nM. In whole cell P388D, murine macrophages the compound has an IC 50 of 540 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
RP 70676 (10 mg/kg, p.o.) is well absorbed with plasma levels in NZW rabbits . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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