RU 26752 , CAS No.76676-33-0

CAS: 76676-33-0 Cat. No.: R1439423 Peso molecolare: 384.55 Numero EC: 636-027-5

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Panoramica

RU 26752 is a steroid hormone receptor antagonist. RU 26752 can prevent hypertension caused by aldosterone in rats.

Specifications

Condizioni di conservazione di stoccaggio

Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Nomi e identificatori

• WGK Germania: 3
• Peso molecolare: 384.55

Application Protocols

No validated bioassay application protocols (e.g., WB, IHC, IF, FC) are applicable to a small-molecule compound like RU 26752, and none are provided here.

General handling protocol for small-molecule stock preparation (guidance)

• Equilibrate vial to room temperature in a desiccator before opening to avoid condensation.
• Prepare a concentrated stock in anhydrous DMSO (e.g., 10–50 mM as solubility permits). Vortex and, if needed, sonicate briefly to aid dissolution.
• Sterile-filter (0.22 µm PTFE) if required for cell-based work and compatible with the compound.
• Aliquot into low-bind microtubes to minimize adsorption and freeze–thaw cycles. Label with concentration, date, and lot.
• For dosing, dilute into pre-warmed assay buffer/media with thorough mixing, ensuring consistent final solvent % across all conditions.

These steps are general best practices and are not item-specific performance claims.

Biological Roles

Item-specific biological function/target

• Not specified for this item in our catalog; no target, pathway, or endogenous role is provided here. Consult primary literature or the CoA if additional annotations are supplied for a specific batch.

General considerations for small-molecule research tools (non-clinical)

• Screening compounds are often used as chemical probes or reference modulators in biochemical or cell-based assays. When the molecular target is unknown or proprietary, users typically perform deconvolution by affinity methods, chemoproteomics, or structure–activity relationship (SAR) studies.
• If the compound is used as a control in a given assay, confirm potency, selectivity, and off-target profiles from independent sources before interpreting biological data.
• Evaluate cytotoxicity and assay interference (e.g., autofluorescence, redox activity, detergent-like effects) using counterscreens.

Important

• For research use only. No medical, diagnostic, or therapeutic use is implied.

Buffer Applications

RU 26752 is a small organic compound, not a buffering agent. As such, established buffer systems (phosphate, HEPES, Tris, acetate, etc.) are not directly applicable to its function.

Practical notes for assay buffers (general)

• When dosing from DMSO stocks, maintain a consistent and minimal final DMSO concentration across control and treatment conditions.
• Consider adding 0.1% BSA or 0.01–0.05% nonionic surfactant to reduce nonspecific adsorption if the compound is hydrophobic, provided these excipients are compatible with your assay.
• Buffer pH and ionic strength should be selected to stabilize the biological target; perform a pH–solubility check to avoid precipitation on dilution.

Item-specific buffer guidance

• Not specified for this item; refer to your assay requirements and any literature associated with RU 26752 if available.

Green Alternatives

This product is a small organic compound (not a solvent). Green-chemistry considerations therefore focus on handling media and workflows rather than replacing the compound itself.

Greener handling choices (general guidance)

• Solvent selection hierarchy: prefer ethanol, isopropanol, or water-based cosolvent systems where compatible with solubility and assay design; reserve DMSO/DMF/MeCN for when necessary.
• Minimize solvent volumes via concentrated DMSO stock solutions and microplate dispensing to reduce waste.
• Use amber vials and room-temperature processes when feasible to limit energy-intensive cold operations (balanced against stability needs).
• Waste management: segregate halogenated vs non-halogenated organic waste; avoid chlorinated solvents unless required by method performance.

Illustrative comparison (general; not item-specific)

• Ethanol vs DMSO: Ethanol offers better biodegradability and lower aquatic toxicity but may provide inferior solubilization for highly lipophilic compounds.
• Aqueous buffers with small % organic vs neat organics: Lower VOC emissions and improved safety; potential precipitation risk must be managed by careful dilution and mixing order.

Note

• If future work involves synthesis using RU 26752 as a substrate, consult green solvent selection guides (CHEM21, ACS GCI) for each transformation step.

Pharmaceutical Uses

No pharmacopeial/excipient status or formulation role is provided for this item. RU 26752 is supplied strictly for research use only.

General context (non-clinical)

• Small molecules in screening libraries may sometimes be evaluated in pre-formulation studies (solubility screening, pH stability, salt selection) to understand developability. Such work is exploratory and not indicative of clinical suitability.
• If you plan to assess formulation-like properties (e.g., for in vitro dosing solutions), standard approaches include:
  • Cosolvent systems (water/PEG 400/ethanol) or cyclodextrin complexation to enhance apparent solubility.
  • pH adjustment if the compound is ionizable.
  • Light and oxidation protection as needed (amberware, inert atmosphere) until specific stability data are known.

Compliance note

• This product is not intended for human or veterinary use, nor for diagnostic procedures.

Physical Properties

Item-specific specs (this product listing)

• Appearance: Not specified for this item; refer to CoA/Spec Sheet.
• Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.
• Melting point, boiling point, density, refractive index, water content, UV cutoff: Not specified for this item; refer to CoA/Spec Sheet.
• Solubility: Not specified for this item; refer to CoA/Spec Sheet.

General guidance (literature/practice, not item specifications)

• For unknown small molecules in screening collections, initial dissolution is commonly attempted in anhydrous DMSO (e.g., preparing 10–50 mM stocks) due to its broad solubilizing power.
• When DMSO is unsuitable, secondary solvents often evaluated include ethanol, methanol, acetonitrile, DMF, and water buffered to neutral pH. Cosolvent systems (e.g., 10–30% DMSO in aqueous buffer) may improve solubility for assay use.
• If pKa data are unknown, a pH-solubility screen across pH 2–10 can reveal ionization-enhanced solubility windows.
• Hygroscopicity and polymorphism are compound-dependent; verify by Karl Fischer and DSC/XRPD if critical to your application.

Important

• Do not treat the above as specifications. For regulated or quantitative work, rely on the batch CoA and your internal qualification.

Quality and Grades

Item-specific details

• Grade/purity: Not specified for this item; refer to CoA/Spec Sheet.
• Appearance: Not specified for this item; refer to CoA/Spec Sheet.

Guidance on interpreting quality for small-molecule library compounds (general information)

• Library/screening compounds are commonly qualified by HPLC area % purity and identity (LC–MS and/or NMR). Typical internal targets at many labs are ≥95% by HPLC, but actual values must be confirmed on the batch CoA.
• Low-UV absorbance solvents are not relevant to solid compounds, but low-residual-solvent levels and acceptable water content (KF) may be important for storage stability and assay reproducibility.
• If a stabilizer, counter-ion, or solvate/hydrate form is present, it should be declared on the CoA; none are specified here for this item.
• For quantitative biology/chemistry, consider independent in-house QC: orthogonal HPLC method, HRMS, and 1H NMR; evaluate salt form and polymorphism if solubility or performance varies.

Documentation

• For batch-specific chromatograms, residual solvent profiles, and impurity summaries, consult the CoA/Spec Sheet or request from Aladdin Scientific technical support.

Reaction and Applications

This product is cataloged within a small-molecule/compound library context and is primarily intended as a research-use reference or screening tool. Without disclosed structure or target, reaction-specific applications cannot be assigned to RU 26752.

General applications for small-molecule standards (non-item-specific)

• Assay development and optimization: establishment of control wells, assessment of signal windows, and benchmarking of detection sensitivity.
• Analytical method development: retention time markers in LC–MS, recovery evaluations, and stability-indicating method qualification (stress testing under light/heat/pH to profile degradants).
• Physicochemical profiling: solubility measurements, logD determination, permeability (e.g., PAMPA) as part of compound triage.

If you intend to use RU 26752 in synthesis

• Absent structural information, no specific transformations can be recommended. If structural details are provided on the CoA, consult literature for functional-group compatible reactions and protective-handling strategies.

Tip

• Establish compound integrity upon receipt (HPLC/LC–MS) and after any prolonged storage or freeze–thaw cycles.

Reaction Conditions

No item-specific reaction condition guidance is possible without the structure or functional-group information of RU 26752.

General guidance if using as a synthetic substrate (not item-specific)

• Solvent: choose based on functional-group compatibility (e.g., polar aprotic for SNAr/couplings; alcohols/ethers for reductions or protections).
• Temperature: begin at ambient and titrate upward as kinetics require, monitoring for decomposition by TLC/HPLC.
• Catalysts/bases: select per transformation class (e.g., Pd-catalyzed couplings with appropriate ligands; carbonate/tertiary amine bases for alkylations) after confirming the presence of compatible handles.
• Workup: quench cautiously; partition between immiscible phases matched to polarity; use antioxidant or acid/base modifiers if instability is observed.
• Analytical control: LC–MS for mass balance, 1H/13C NMR for structure, and, if relevant, chiral HPLC for enantioselectivity.

Note

• Treat all of the above as general literature practice. For RU 26752 specifically, consult the CoA/Spec Sheet and any primary references you may locate.

Safety and Handling

Authoritative safety information must be taken from the SDS for RU 26752.

Item-specific hazard data (this listing)

• Signal word: Not specified for this item; refer to SDS.
• H-statements/GHS classification/pictograms: Not specified for this item; refer to SDS.

General laboratory precautions (good practice; not a substitute for SDS)

• Handle in a chemical fume hood and avoid inhalation, ingestion, or skin/eye contact. Wear appropriate PPE: lab coat, safety glasses, and chemical-resistant gloves (e.g., nitrile). Consider double-gloving for DMSO solutions.
• Avoid contact with strong oxidizers and strong acids/bases unless compatibility is established.
• If dust or aerosols may form, use local exhaust/respirator per institutional policy.
• First-aid overview: in case of skin contact, wash with soap and water; eye contact, rinse with water for several minutes and seek medical advice; if inhaled, move to fresh air; if ingested, rinse mouth and seek medical attention. Always follow the SDS-specific instructions when available.
• Spill response: contain and absorb with inert material; avoid discharge to drains. Dispose of waste according to local regulations.

Storage and shipping

• Storage condition (item-specific): Store at -20°C.
• Shipping (item-specific): Shipped in ice chest with ice pads to maintain cold chain.
• Allow to equilibrate to room temperature in a desiccated environment before opening to minimize condensation.

Solvent Selection

Because physicochemical parameters are not listed for this item, use a tiered solvent strategy to establish working stocks.

Practical approach (general guidance)

• Primary stock solvent: DMSO (anhydrous) is typically the first choice for small molecules; prepare 10–50 mM stocks as solubility permits.
• Secondary organics: If DMSO is undesirable, evaluate DMF, acetonitrile, ethanol, or methanol. Avoid water-reactive systems until compatibility is known.
• Aqueous use: For assay additions, dilute DMSO stocks into buffered media, maintaining final DMSO ≤0.1–1% v/v as assay tolerance permits. Use surfactants (e.g., 0.01–0.05% Tween-20) only if compatible with your biology/analytics.
• pH leverage: If ionizable, adjust buffer pH to favor solubilized form (acidic pH for bases, basic pH for acids). Without pKa data, run a mini pH–solubility screen.

Comparison (general)

• DMSO: maximal solubility, broad compatibility; can permeabilize cells and extract plastics.
• DMF/MeCN: good solvent power; consider toxicity and material compatibility.
• EtOH/MeOH: more biocompatible but narrower solubility domain.

Notes

• Filter 0.22 µm if particulates persist and the compound is not adsorptive. Verify no loss to filters by recovery check.

Storage and Reconstitution

Item-specific conditions

• Storage: Store at -20°C.
• Shipping: Ice chest with ice pads to maintain cold chain.

General best practices (not item-specific specifications)

• Keep the vial tightly closed under dry, inert atmosphere (e.g., nitrogen/argon) if long-term storage is planned, especially for moisture- or oxygen-sensitive compounds. Use desiccant.
• Protect from light in amber containers until photostability is known.
• Minimize freeze–thaw cycles; aliquot upon first opening. Track cumulative time at ambient temperature.

Reconstitution guidance

• Solvent choice: Start with anhydrous DMSO to prepare a concentrated stock solution (e.g., 10–50 mM as permitted by solubility). If DMSO is unsuitable, trial DMF, acetonitrile, ethanol, or methanol.
• Technique: Allow solid to reach room temperature before opening. Weigh quickly to limit moisture uptake. Add solvent incrementally with vortexing; sonicate briefly if needed.
• Storage of solutions: Store aliquoted stock solutions at −20°C or −80°C, protected from light; avoid repeated freeze–thaw. Verify stability by periodic LC–MS/HPLC.

Research use note

• For research use only. Refer to the CoA/Spec Sheet and SDS for batch-specific guidance and safety information.

Structure and Identity

• Product name: RU 26752 (SKU: R1439423)
• CAS: 76676-33-0
• InChIKey: Not specified for this item; refer to CoA/Spec Sheet.
• SMILES: Not specified for this item; refer to CoA/Spec Sheet.
• Molecular formula: Not specified for this item; refer to CoA/Spec Sheet.
• Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.

Structural description

• Item-specific structural features (functional groups, ring systems, stereochemistry): Not specified for this item; refer to CoA/Spec Sheet.

Notes

• RU 26752 is listed in our Small Molecules & Compound Libraries category; it is typically supplied as a research-use-only small molecule standard or screening compound. In the absence of structural identifiers on this page, please consult the batch-specific Certificate of Analysis (CoA) or contact Aladdin Scientific for structural confirmation data (NMR/LC–MS/HPLC chromatogram) where available.

Synthetic Utility

Item-specific functional groups and synthetic behavior are not disclosed for RU 26752 in this listing; therefore, no definitive synthetic roles can be assigned.

General remarks (for small organic molecules)

• If RU 26752 contains common functional handles (e.g., halides, nitro, nitrile, esters, amides), it may in principle serve as a substrate for cross-coupling, reductions, hydrolyses, or other transformations. Verification requires structural information (SMILES/InChI) from the CoA.
• Prior to any derivatization campaign, confirm identity and purity by orthogonal methods and assess stability under basic/acidic and redox conditions to avoid degradation or rearrangement.
• Where stereochemistry is present, track enantiopurity and diastereomeric ratios by chiral HPLC or NMR with chiral shift reagents.

Recommendation

• Obtain the structural file (SDF/SMILES) from Aladdin Scientific (if available) to plan retrosynthetic routes or late-stage diversification.

Target Specificity

Not applicable. RU 26752 is a small molecule, not an antibody or biological macromolecule. No antigen/epitope, clone, isotype, or species reactivity information applies to this product.

If RU 26752 is used as a chemical probe in your research, consult primary literature or internal data to determine molecular targets, selectivity, and off-target profiles. Such information is not provided in this catalog entry.