10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 10 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Rutaecarpine (Rutecarpine) is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs; a new class ofCOX-2inhibitor.
In vitro
Rutaecarpine is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs, which has shown a variety of intriguing biological properties such as anti-thrombotic, anticancer, anti-inflammatory and analgesic, anti-obesity and thermoregulatory, vasorelaxing activity, as well as effects on the cardiovascular and endocrine systems.
In vivo
LD50: Mice 65mg/kg (i.v.).
Cell Data
cell lines：Ba/F3 cells and primary Ph+ leukemia cells
Concentrations：
Incubation Time：
Powder Purity:≥99%
| Isomeri SMILES | C1CN2C(=NC3=CC=CC=C3C2=O)C4=C1C5=CC=CC=C5N4 |
|---|---|
| WGK Germania | 3 |
| PubChem CID | 65752 |
| Numero UN | 2811 |
| Peso molecolare | 287.32 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Solubilità | Solubility (25°C) In vitro DMSO: 32 mg/mL (96.28 mM); Water: Insoluble; Ethanol: Insoluble; |
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| Punto di fusione (°C) | 262 °C |
| 1. Yun Yang, Yuan Xiong, Guanghao Zhu, Mengru Sun, Kun Zou, Yitian Zhao, Yong Zhang, Zhijian Xu, Yiming Li, Weiliang Zhu, Qi Jia, Bo Li, Guangbo Ge. (2023) Discovery of seven-membered ring berberine analogues as highly potent and specific hCES2A inhibitors. CHEMICO-BIOLOGICAL INTERACTIONS, [PMID:37080375] [10.1016/j.cbi.2023.110501] |
| 2. Lushan Yu, Zhangting Wang, Minmin Huang, Yingying Li, Kui Zeng, Jinxiu Lei, Haihong Hu, Baian Chen, Jing Lu, Wen Xie, Su Zeng. (2015) Evodia alkaloids suppress gluconeogenesis and lipogenesis by activating the constitutive androstane receptor. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, [PMID:26455953] [10.1016/j.bbagrm.2015.10.001] |
| 3. Junyan Wang, Minmin Huang, Haihong Hu, Lushan Yu, Su Zeng. (2014) Pregnane X receptor-mediated transcriptional activation of UDP-glucuronosyltransferase 1A1 by natural constituents from foods and herbs. FOOD CHEMISTRY, [PMID:24996308] [10.1016/j.foodchem.2014.05.004] |
| 4. Xue-qi Liu, Juan Jin, Zeng Li, Ling Jiang, Yu-hang Dong, Yu-ting Cai, Ming-fei Wu, Jia-nan Wang, Tao-tao Ma, Jia-gen Wen, Ming-ming Liu, Jun Li, Yong-gui Wu, Xiao-ming Meng. (2020) Rutaecarpine derivative Cpd-6c alleviates acute kidney injury by targeting PDE4B, a key enzyme mediating inflammation in cisplatin nephropathy. BIOCHEMICAL PHARMACOLOGY, [PMID:32622666] [10.1016/j.bcp.2020.114132] |
| 5. Yao Sun, Pengfei Li, Ting Wang, Liting Qin, Gege Cheng, Liqun Shen, Xingdong Yao, Shaoping Wei, Jianxin Jiang, Fuhou Lei. (2019) Alkaloid purification using rosin-based polymer-bonded silica stationary phase in HPLC. JOURNAL OF SEPARATION SCIENCE, 42 (24): (3646-3652). [PMID:31613051] [10.1002/jssc.201900835] |
| 6. Jiahui Wang, Min Zhou, Rong Fu, Ju Ge, Wei Yang, Xufeng Hong, Congli Sun, Xiaobin Liao, Yan Zhao, Zhaoyang Wang. (2024) Iron Molybdenum Sulfide-Supported Ultrafine Ru Nanoclusters for Robust Sulfion Degradation-Assisted Hydrogen Production. ADVANCED FUNCTIONAL MATERIALS, [PMID:] [10.1002/adfm.202315326] |
| 7. Yan Liu, Feng Qi, Lun-Jian Xiang, Zhu-Jun Yi, Sheng-Wei Li. (2025) Rutaecarpine alleviates hepatic ischemia‒reperfusion injury in liver transplantation by inhibiting inflammatory response and oxidative stress. Frontiers in Pharmacology, [PMID:39963247] [10.3389/fphar.2025.1539744] |
| 8. Juan Chen, Zi-yun Hu, Yu Ma, Shan Jiang, Jiu-yu Yin, Yu-kai Wang, Yong-gui Wu, Xue-qi Liu. (2024) Rutaecarpine alleviates inflammation and fibrosis by targeting CK2α in diabetic nephropathy. BIOMEDICINE & PHARMACOTHERAPY, [PMID:39353318] [10.1016/j.biopha.2024.117499] |
| 9. Xin Li, Aiyu Niu, Shanshan Yang, Fei Liu. (2024) The reduction of nitrobenzene by Fe(II)-goethite-hematite heterogeneous systems: Insight from thermodynamic parameters of reduction potential. JOURNAL OF ENVIRONMENTAL MANAGEMENT, [PMID:39250851] [10.1016/j.jenvman.2024.122404] |
| 10. Huiying Wu, Lei Zeng, Mengling Wei, Liwei Chen, Jiajia Guo, Yun Huang, Fuhou Lei, Hao Li. (2025) Preparation of mixed-mode chromatographic stationary phases based on modified rosin and its application in the separation of natural medicines. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2025.114110] |
