S-Me-DM1 , CAS No.912569-84-7

CAS: 912569-84-7 Cat. No.: S276125 Formula: C₃₆H₅₀ClN₃O₁₀S Peso molecolare: 752.31 PubChem CID: 154705356

Synonyms

N2'-Deacetyl-N2'-(3-thiomethyl-1-oxopropyl)-maytansine

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Panoramica

Shipped at 4°C. Store at -20°C. Store under desiccating conditions.

Specifications

Sinonimi

N2'-Deacetyl-N2'-(3-thiomethyl-1-oxopropyl)-maytansine

Meccanismi biochimici e fisiologici

Active metabolite of Maytansine that inhibits in vitro polymerization of tubulin. Accumulates in cells and induces mitotic arrest.

Condizioni di conservazione di stoccaggio

Store at -20°C,Desiccated

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Nomi e identificatori

Sorrisi canonici

CC1C2CC(C(C=CC=C(CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)CC(C4(C1O4)C)OC(=O)C(C)N(C)C(=O)CCSC)C)C)OC)(NC(=O)O2)O

IUPAC Name

[(1S,2R,3S,5S,6S,16Z,18Z,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2S)-2-[methyl(3-methylsulfanylpropanoyl)amino]propanoate

InChIKey

PLYHSTGTQYPYMT-UDXCHANISA-N

INCHI

1S/C36H50ClN3O10S/c1-20-11-10-12-27(47-8)36(45)19-26(48-34(44)38-36)21(2)32-35(4,50-32)28(49-33(43)22(3)39(5)29(41)13-14-51-9)18-30(42)40(6)24-16-23(15-20)17-25(46-7)31(24)37/h10-12,16-17,21-22,26-28,32,45H,13-15,18-19H2,1-9H3,(H,38,44)/b12-10-,20-11-/t21-,22+,26+,27-,28+,32+,35+,36+/m1/s1

PubChem CID

154705356

Peso molecolare

752.31

Proprietà chimiche e fisiche

• Solubilità: Solubilizes at ~3mg/mL in DMSO, ~3mg/mL in Chloroform, and ~3mg/mL in MeOH