(S,R,S)-AHPC-PEG₁-Alkyne - ≥95%

Cat. No.: S463566

GRADE & PURITY ≥95%

Synonyms

CrosslinkerE3 Ligase ligand conjugate, Protein degrader building block for PROTAC research, VH032 conjugate, Template for synthesis of targeted protein degrader, (2S,4R)-1-((S)-3,3-Dimethyl-2-(3-(prop-2-yn-1-yloxy)propanamido)butanoyl

Storage

Store at 2-8°C

Shipped In

Wet ice

Panoramica

Description

Protein degrader builiding block (S,R,S)-AHPC-PEG1-NH2(HCl salt) enables the synthesis of molecules fortargeted protein degradation andPROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blockswith a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Specifications

Sinonimi

CrosslinkerE3 Ligase ligand conjugate, Protein degrader building block for PROTAC research, VH032 conjugate, Template for synthesis of targeted protein degrader, (2S,4R)-1-((S)-3,3-Dimethyl-2-(3-(prop-2-yn-1-yloxy)propanamido)butanoyl

Specifiche e purezza

≥95%

Informazioni legali

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Condizioni di conservazione di stoccaggio

Store at 2-8°C

Spedito in

Wet ice

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Purezza

≥95%