S3I-201 - ≥96% , CAS No.501919-59-1

Name: S3I-201 - ≥96% , CAS No.501919-59-1
SKU: S129625
Availability: InStock

CAS: 501919-59-1 Cat. No.: S129625 Formula: C₁₆H₁₅NO₇S Peso molecolare: 365.36 PubChem CID: 252682

COA

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S3I-201 - ≥96% CAS No(501919-59-1) by Aladdin Scientific

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Disponibile su ordine

GRADE & PURITY ≥96%

Synonyms

NSC 74859 | AKOS016366328 | Q-103549 | SCHEMBL4456216 | 2-Hydroxy-4-(((4-methylphenyl)sulfonyloxy)acetyl)amino)-benzoic acid | CHEBI:91224 | S31-201 | AC-32045 | EX-A342 | S3I201 | s-3i-201 | S3I-201 | MLS002701911 | GLG-302 | S3I 201 | JG1E8503OI | NCGC0

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Panoramica Specifications Nomi e identificatori Documentazione Advanced Data Taxonomic Classification Struttura 3D Obiettivi associati (umani) Obiettivi associati (non umani) Meccanismi d'azione Certificati (CoA, COO, BSE/TSE e tabella di analisi) Proprietà chimiche e fisiche Domande frequenti e articoli Calcolatori di soluzioni Recensioni

🧪

Why this grade

≥96% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Panoramica

S3I-201 (NSC 74859) effectively inhibits the DNA binding activity of STAT3 with IC50 of 86 μM, but has low inhibitory activity on STAT1 and STAT5.

S2I-201 is a small molecule inhibitor that provides a pathway to rational combination therapies for Melanoma.

Specifications

Sinonimi

Specifiche e purezza

≥96%

Meccanismi biochimici e fisiologici

NSC 74859 (S3I-201) inhibits Stat3-Stat3 complex formation and Stat3 DNA-binding (IC50 =86 ±33μM) and transcriptional activities. Furthermore, S31-201 inhibits growth and induces apoptosis preferentially in tumor cells that contain persistently

Condizioni di conservazione di stoccaggio

Store at -20°C,Argon charged

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purezza

≥96%

Nomi e identificatori

Pubchem Sid

504758127

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504758127

Sorrisi canonici

CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O

IUPAC Name

2-hydroxy-4-[[2-(4-methylphenyl)sulfonyloxyacetyl]amino]benzoic acid

InChIKey

HWNUSGNZBAISFM-UHFFFAOYSA-N

INCHI

1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21)

Isomeri SMILES

CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O

WGK Germania

PubChem CID

252682

Peso molecolare

365.36

Documentazione

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Classe Benzene and substituted derivatives
    - Subclass Benzoic acids and derivatives

Kingdom	Organic compounds
Superclass	Benzenoids
Classe	Benzene and substituted derivatives
Subclass	Benzoic acids and derivatives
Intermediate Tree Nodes	Not available
Direct Parent	Acylaminobenzoic acid and derivatives
Alternative Parents	p-Methylbenzenesulfonates Benzenesulfonate esters Tosyl compounds Salicylic acids Anilides Arylsulfonic acids and derivatives Benzenesulfonyl compounds Benzoic acids N-arylamides Benzoyl derivatives 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Organosulfonic acid esters Vinylogous acids Sulfonyls Secondary carboxylic acid amides Monocarboxylic acids and derivatives Carboxylic acids Organic oxides Hydrocarbon derivatives Carbonyl compounds Organopnictogen compounds
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	Acylaminobenzoic acid or derivatives - P-methylbenzenesulfonate - Benzenesulfonate ester - Salicylic acid - Benzenesulfonate - Tosyl compound - Salicylic acid or derivatives - Hydroxybenzoic acid - Arylsulfonic acid or derivatives - Benzoic acid - Anilide - Benzenesulfonyl group - N-arylamide - Benzoyl - Toluene - 1-hydroxy-4-unsubstituted benzenoid - Phenol - 1-hydroxy-2-unsubstituted benzenoid - Organosulfonic acid ester - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Sulfonyl - Vinylogous acid - Secondary carboxylic acid amide - Carboxamide group - Carboxylic acid derivative - Carboxylic acid - Monocarboxylic acid or derivatives - Organic oxygen compound - Hydrocarbon derivative - Organic nitrogen compound - Organic oxide - Carbonyl group - Organopnictogen compound - Organonitrogen compound - Organooxygen compound - Organosulfur compound - Aromatic homomonocyclic compound
Descrizione	This compound belongs to the class of organic compounds known as acylaminobenzoic acid and derivatives. These are derivatives of amino benzoic acid derivatives where the amine group is N-acylated.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Struttura 3D

Obiettivi associati (umani)

STAT3 Tchem Signal transducer and activator of transcription 3 (3313 Activities)

Discover Target: STAT3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (36611 Activities)

Discover Target: PIN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Huh-7 (12904 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MDA-MB-468 (9477 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A549 (127892 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SNU-398 (481 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HepG2 (196354 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MDA-MB-435 (38290 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MDA-MB-231 (73002 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FEN1 Tchem Flap endonuclease 1 (12055 Activities)

Discover Target: FEN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLK Tbio DNA polymerase kappa (8653 Activities)

Discover Target: POLK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLI Tchem DNA polymerase iota (116820 Activities)

Discover Target: POLI

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLH Tchem DNA polymerase eta (21678 Activities)

Discover Target: POLH

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)

Discover Target: KDM4A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SNU-449 (154 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SNU-475 (119 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SMAD3 Tchem Mothers against decapentaplegic homolog 3 (68039 Activities)

Discover Target: SMAD3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CTDSP1 Tchem Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (1031 Activities)

Discover Target: CTDSP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

WRN Tbio Werner syndrome ATP-dependent helicase (8824 Activities)

Discover Target: WRN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SIRT5 Tchem NAD-dependent protein deacylase sirtuin-5, mitochondrial (1056 Activities)

Discover Target: SIRT5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Obiettivi associati (non umani)

tat Human immunodeficiency virus type 1 Tat protein (75 Activities)

Discover Target: tat

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NIH3T3 (5395 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Stat1 Signal transducer and activator of transcription 1 (5 Activities)

Discover Target: Stat1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Phosphoglycerate kinase, glycosomal (2184 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

clpP ATP-dependent Clp protease proteolytic subunit (245 Activities)

Discover Target: clpP

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Stat3 Signal transducer and activator of transcription 1/ 3 (13 Activities)

Discover Target: Stat3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Meccanismi d'azione

Certificati (CoA, COO, BSE/TSE e tabella di analisi)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number	Certificate Type	Data	Oggetto
I2127285	Certificate of Analysis	Apr 03, 2025	S129625
I2127286	Certificate of Analysis	Apr 03, 2025	S129625
I2127287	Certificate of Analysis	Apr 03, 2025	S129625
I2127331	Certificate of Analysis	Apr 03, 2025	S129625
I2127333	Certificate of Analysis	Apr 03, 2025	S129625

Proprietà chimiche e fisiche

Solubilità	DMSO 73 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
Sensibilità	Moisture sensitive
Peso molecolare	365.400 g/mol
XLogP3	3.000
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	6
Exact Mass	365.057 Da
Monoisotopic Mass	365.057 Da
Topological Polar Surface Area	138.000 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	578.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Domande frequenti e articoli

Angiogenic Factors: Molecular Classes, Regulatory Mechanisms, and Experimental as Well as Translational Applications

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

Tags:

FGF VEGF Angiogenesis Extracellular matrix Angiopoietin Notch Endothelial cells Anti-angiogenic therapy Tissue repair

Key Nodes and Representative Mechanisms in Angiogenic Regulatory Networks: A Structured Review

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

Tags:

Angiogenesis Exosomes Extracellular matrix Wnt/β-catenin Tumor microenvironment Inflammation and immunity Hypoxia

L-22 Signaling Pathway: Barrier-Oriented Signaling Features and Tissue Response Mechanisms

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

Tags:

Antimicrobial peptides Tissue repair IL-22 IL-22RA1 IL-10R2 STAT3 IL-22BP barrier tissues

Regulatory Roles of the SOCS Family in the JAK-STAT Pathway, Immune Inflammation, and Disease Models

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

Tags:

Disease Models SOCS1 SOCS3 CISH SOCS family JAK-STAT pathway STAT phosphorylation Immune inflammation

Inflammatory Signaling Pathway Research Guide: Danger Signal Recognition, Core Signaling Modules, Detection Readouts, and Representative Research Reagents

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

Tags:

Inflammatory Response inflammatory signaling

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S3I-201 - ≥96% , CAS No.501919-59-1

Storage & shipping

Quality documents

Literature proof

Panoramica

Specifications

Documentazione

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Recensioni dei clienti

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