10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
S3I-201 (NSC 74859) shows potent inhibition ofSTAT3DNA-binding activity withIC50of 86 μM in cell-free assays, and low activity towards STAT1 and STAT5.
In vitro
S3I-201 inhibits growth and induces apoptosis preferentially in tumor cells that contain persistently activated Stat3 by inhibiting Stat3·Stat3 complex formation and Stat3 DNA-binding and transcriptional activitie. Moreover, S3I-201 also inhibits the expression of the Stat3-regulated genes encoding cyclin D1, Bcl-xL, and survivin. S3I-201 inhibits breast carcinoma MDA-MB-435, MDA-MB-453 and MDA-MB-231 cell lines with IC50 of 100 μM. In addition, the cells with impaired TGF-β signaling are four times as sensitive to the STAT3 inhibitor S3I-201. A recent study shows that S3I-201 potentiates the antiproliferative effect of cetuximab in HepG2 and Huh-7 cells via the STAT3 signalling pathway.
In vivo
S3I-201 (5 mg/kg, i.v. every 2 or every 3 days) shows the antitumor efficacy in mouse models with human breast tumor xenografts that harbor constitutively active Stat3. S3I-201 treatment reduces Varicella-zoster virus (VZV) replication on the basis of the bioluminescence signal and the number of positive skin xenografts compared with DMSO-treated mice by inhibiting STAT3 phosphorylation.
Cell Data
cell lines：
Concentrations：~ 250 μM
Incubation Time：72 hours
Powder Purity:≥99%
| Isomeri SMILES | CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O |
|---|---|
| WGK Germania | 3 |
| PubChem CID | 252682 |
| Peso molecolare | 365.36 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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| Lot Number | Certificate Type | Data | Oggetto |
|---|---|---|---|
 K2222022 | Certificate of Analysis | Jul 22, 2026 | S408496 |
| Solubilità | Solubility (25°C) In vitro Ethanol: 3 mg/mL (9.63 mM); DMSO: 1 mg/mL (3.21 mM); Water: Insoluble; |
|---|
