SB505124 - Moligand™, 10mM in DMSO , Inhibitor of transforming growth factor beta receptor 1, CAS No.694433-59-5, Inhibitor of transforming growth factor beta receptor 1

CAS: 694433-59-5 Cat. No.: S408748 Formula: C₂₀H₂₁N₃O₂ Peso molecolare: 335.4 PubChem CID: 9858940

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

2-(4-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

SB505124 is a selective inhibitor ofTGFβRforALK4,ALK5withIC50of 129 nM and 47 nM in cell-free assays, respectively, also inhibitsALK7, but does not inhibit ALK1, 2, 3, or 6.
In vitro

SB505124 is identified as a reversible ATP competitive and selective ALK inhibitor of ALK4 and ALK5. SB505124 shows no toxicity to renal epithelial A498 cells at concentrations up to 100 μM for 48 hours, and blocks TGF-β–induced apoptosis of FaO cells and NRP 154 cells in a concentration-dependent manner. In human umbilical vein endothelial cells (HUVEC), SB505124 (500 nM) blocks the changes of TGF-β1 on F-actin assembly and prevents ROS production induced by TGF-β. By inhibiting TGF-beta1 signaling, SB505124 leads to decreased deferoxamine (DFO)-induced neurogenesis. A recent study shows that SB505124 suppresses the migration and invasion of breast cancer MCF-7-M5 cells.

In vivo

In a rabbit GFS model, SB505124 decreased the intraocular pressure (IOP) levels and reduces subconjunctival cell infiltration and scarring at the surgical site in the GFS. In tacrolimus (TAC)-treated mice and FK12EC KO mice, SB505124 prevents the activation of endothelial TGF-β receptors and induction of renal arteriolar hyalinosis.
Cell Data

cell lines：

Concentrations：0-10 μM

Incubation Time：48 hours

Powder Purity:≥98%

Specifications

Sinonimi

2-(4-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine

Specifiche e purezza

Moligand™, 10mM in DMSO

Meccanismi biochimici e fisiologici

SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5 with IC50 of 129 nM and 47 nM in cell-free assays, respectively, also inhibits ALK7, but does not inhibit ALK1, 2, 3, or 6.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

INHIBITOR

Meccanismo d'azione

Inhibitor of transforming growth factor beta receptor 1

Nomi e identificatori

• Isomeri SMILES: CC1=NC(=CC=C1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=C(C=C3)OCO4
• PubChem CID: 9858940
• Peso molecolare: 335.4

Obiettivi associati (umani)

TGFBR1 Tchem TGF-beta receptor type-1 (1 Activities)

Discover Target: TGFBR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Proprietà chimiche e fisiche

• Solubilità: Solubility (25°C) In vitro DMSO: 48 mg/mL (201.46 mM); Ethanol: 25 mg/mL (104.92 mM); Water: Insoluble
• Punto di fusione (°C): 168 °C

Domande frequenti

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 694433-59-5, the molecular formula is C20H21N3O2, and the molecular weight is 335.4 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.