10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
SBI-0640756 SBI-0640756 is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. It can also suppress AKT and NF-kB signaling.
Targets
eIF4G1
In vitro
SBI-756 impaired the eIF4F complex assembly independently of mTOR and attenuated growth of BRAF-resistant and BRAF-independent melanomas.It also supresses AKT and NF-kB signaling. SBI-756 inhibits the growth of NRAS, BRAF, and NF1-mutant melanomas in vitro.
In vivo
SBI-756 delays the onset and reduces the incidence of Nras/Ink4a melanomas in vivo.
Cell Research(from reference)
Cell lines：Melanoma lines
Concentrations：1, 2, 5 μmol/L
Incubation Time：48 h
| ALogP | 4.273 |
|---|---|
| Conteggio HBD | 1 |
| Legame rotabile | 4 |
| Pubchem Sid | 528767054 |
|---|---|
| Sorrisi canonici | C1=CC=C(C=C1)C2=C(C(=O)NC3=C2C=C(C=C3)Cl)C(=O)C=CC4=CC(=CN=C4)F |
| IUPAC Name | 6-chloro-3-[(E)-3-(5-fluoropyridin-3-yl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one |
| InChIKey | VVWGPQZBDQVQRC-RMKNXTFCSA-N |
| INCHI | 1S/C23H14ClFN2O2/c24-16-7-8-19-18(11-16)21(15-4-2-1-3-5-15)22(23(29)27-19)20(28)9-6-14-10-17(25)13-26-12-14/h1-13H,(H,27,29)/b9-6+ |
| PubChem CID | 121241171 |
| Peso molecolare | 404.82 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Classe | Quinolines and derivatives |
| Subclass | Phenylquinolines |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Phenylquinolines |
| Alternative Parents | Phenylpyridines Hydroquinolones Chloroquinolines Hydroquinolines Aryl ketones Pyridinones Benzene and substituted derivatives Aryl fluorides Aryl chlorides Vinylogous amides Heteroaromatic compounds Enones Acryloyl compounds Lactams Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organofluorides Organochlorides Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Phenylquinoline - 4-phenylpyridine - Haloquinoline - Chloroquinoline - Dihydroquinolone - Dihydroquinoline - Aryl ketone - Pyridinone - Benzenoid - Pyridine - Monocyclic benzene moiety - Aryl halide - Aryl fluoride - Aryl chloride - Heteroaromatic compound - Vinylogous amide - Alpha,beta-unsaturated ketone - Enone - Acryloyl-group - Lactam - Ketone - Azacycle - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organofluoride - Organochloride - Organohalogen compound - Aromatic heteropolycyclic compound |
| Descrizione | This compound belongs to the class of organic compounds known as phenylquinolines. These are heterocyclic compounds containing a quinoline moiety substituted with a phenyl group. |
| External Descriptors | Not available |
| DMSO (mg/mL) Solubilità massima | 80 |
|---|---|
| DMSO (mM) Solubilità massima | 197.6186947 |
| Acqua (mg/mL) Solubilità massima | ＜1 |
| Peso molecolare | 404.800 g/mol |
| XLogP3 | 4.100 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 4 |
| Exact Mass | 404.073 Da |
| Monoisotopic Mass | 404.073 Da |
| Topological Polar Surface Area | 59.100 Ų |
| Heavy Atom Count | 29 |
| Formal Charge | 0 |
| Complexity | 701.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 1 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 1 |
| Covalently-Bonded Unit Count | 1 |
