≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
SBI-477 SBI-477 is an insulin signaling inhibitor that deactivates the transcription factor MondoA , leading to reduced expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domain-containing 4 (ARRDC4) . SBI-477 inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes.
Targets
MondoA ; TXNIP ; ARRDC4 ; TAG
| Pubchem Sid | 528767056 |
|---|---|
| Sorrisi canonici | COC1=CC=C(C=C1)C2=CSC(=N2)NC(=O)C3=CC(=C(C=C3)OCC(=O)N4CCOCC4)OC |
| IUPAC Name | 3-methoxy-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-4-(2-morpholin-4-yl-2-oxoethoxy)benzamide |
| InChIKey | SJPVXFZDWAIFFT-UHFFFAOYSA-N |
| INCHI | 1S/C24H25N3O6S/c1-30-18-6-3-16(4-7-18)19-15-34-24(25-19)26-23(29)17-5-8-20(21(13-17)31-2)33-14-22(28)27-9-11-32-12-10-27/h3-8,13,15H,9-12,14H2,1-2H3,(H,25,26,29) |
| Isomeri SMILES | COC1=CC=C(C=C1)C2=CSC(=N2)NC(=O)C3=CC(=C(C=C3)OCC(=O)N4CCOCC4)OC |
| PubChem CID | 2469116 |
| Peso molecolare | 483.54 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Classe | Benzene and substituted derivatives |
| Subclass | Benzoic acids and derivatives |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Benzamides |
| Alternative Parents | Anisoles Benzoyl derivatives Methoxybenzenes Phenoxy compounds 2,4-disubstituted thiazoles Alkyl aryl ethers Morpholines Heteroaromatic compounds Tertiary carboxylic acid amides Secondary carboxylic acid amides Dialkyl ethers Oxacyclic compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds |
| Molecular Framework | Aromatic heteromonocyclic compounds |
| Substituents | Benzamide - Phenoxy compound - Anisole - Benzoyl - Methoxybenzene - Phenol ether - 2,4-disubstituted 1,3-thiazole - Alkyl aryl ether - Morpholine - Oxazinane - Azole - Heteroaromatic compound - Thiazole - Tertiary carboxylic acid amide - Carboxamide group - Secondary carboxylic acid amide - Oxacycle - Azacycle - Carboxylic acid derivative - Dialkyl ether - Ether - Organoheterocyclic compound - Organic oxygen compound - Carbonyl group - Organic nitrogen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organonitrogen compound - Organooxygen compound - Aromatic heteromonocyclic compound |
| Descrizione | This compound belongs to the class of organic compounds known as benzamides. These are organic compounds containing a carboxamido substituent attached to a benzene ring. |
| External Descriptors | Not available |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Data | Oggetto |
|---|---|---|---|
 G2422326 | Certificate of Analysis | Mar 26, 2024 | S412852 |
| G2422327 | Certificate of Analysis | Mar 26, 2024 | S412852 |
| G2422328 | Certificate of Analysis | Mar 26, 2024 | S412852 |
| G2422329 | Certificate of Analysis | Mar 26, 2024 | S412852 |
| G2422330 | Certificate of Analysis | Mar 26, 2024 | S412852 |
| G2422331 | Certificate of Analysis | Mar 26, 2024 | S412852 |
| G2422332 | Certificate of Analysis | Mar 26, 2024 | S412852 |
| G2422333 | Certificate of Analysis | Mar 26, 2024 | S412852 |
| Solubilità | Solubility (25°C) In vitro DMSO: 97 mg/mL (200.6 mM); Water: Insoluble; Ethanol: Insoluble; |
|---|---|
| Peso molecolare | 483.500 g/mol |
| XLogP3 | 2.900 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 8 |
| Exact Mass | 483.146 Da |
| Monoisotopic Mass | 483.146 Da |
| Topological Polar Surface Area | 127.000 Ų |
| Heavy Atom Count | 34 |
| Formal Charge | 0 |
| Complexity | 671.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
