SC79 - 10mM in DMSO , CAS No.305834-79-1

CAS: 305834-79-1 Cat. No.: S408491 Formula: C₁₇H₁₇ClN₂O₅ Peso molecolare: 364.8 Numero EC: 974-068-3 PubChem CID: 2810830

QUALITÀ & PUREZZA 10mM in DMSO

Synonyms

ethyl 2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

SC79 SC79 is a brain-penetrable Akt phosphorylation activator and an inhibitor of Akt-PH domain translocation.
In vitro

SC79 suppresses PH_AKTM-GFP plasma membrane translocation, and enhances phosphorylation of all three Akt isoforms in HEK293, HeLa, HL60, NB4, and HsSulton (B cells) cells. SC79 reduces neuronal excitotoxicity and prevents stroke-induced neuronal death. SC79 restores proliferation of BRAT1 knockdown cells, and reduces the production of superoxide in mitochondria of MitoSox positive cells.

In vivo

In the permanent focal cerebral ischemia mouse model, SC79 (0.04 mg/g, i.p.) enables the cytosolic activation of Akt, and recapitulates the primary cellular function of Akt signaling, resulting in augmented neuronal survival.
Cell Data

cell lines：

Concentrations：8 μg/mL

Incubation Time：24 h

Powder Purity:

Specifiche

Sinonimi

ethyl 2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

SC79 is a brain-penetrable Akt phosphorylation activator and an inhibitor of Akt-PH domain translocation.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

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Nomi e identificatori

Isomeri SMILES

CCOC(=O)C1=C(OC2=C(C1C(C#N)C(=O)OCC)C=C(C=C2)Cl)N

PubChem CID

2810830

Peso molecolare

364.8