Schizandrin B - 10mM in DMSO , CAS No.61281-37-6

CAS: 61281-37-6 Cat. No.: S425073 Formula: C₂₃H₂₈O₆ Peso molecolare: 400.4648 PubChem CID: 108130

GRADE & PURITY 10mM in DMSO

Synonyms

BDBM50341711 | HY-N0089 | SR-05000002175-2 | BCP30085 | InChI=1/C9H8N2O/c1-6-9(12)11-8-5-3-2-4-7(8)10-6/h2-5H,1H3,(H,11,12 | S(-) Schisandrin B | DIACEREIN [MART.] | S(-) Wuweizisu B | Q-100707 | FT-0775855 | SCHEMBL3380716 | (5S,6S,7S,13aS)-5,6,7,8-Tetra

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Schisandrin B exhibits antioxidant activity which may be responsible for its hepatic protecting activity. It was shown to increase glutathione level and Dt-diaphorase enzyme activity
A compound shown to up-regulate cellular antioxidant response.

Specifications

Sinonimi

BDBM50341711 | HY-N0089 | SR-05000002175-2 | BCP30085 | InChI=1/C9H8N2O/c1-6-9(12)11-8-5-3-2-4-7(8)10-6/h2-5H,1H3,(H,11,12 | S(-) Schisandrin B | DIACEREIN [MART.] | S(-) Wuweizisu B | Q-100707 | FT-0775855 | SCHEMBL3380716 | (5S,6S,7S,13aS)-5,6,7,8-Tetra

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

Anti-inflammatory and antioxidant agent. Inhibits ROS production in microglia. Modulates NFκB and Nrf2. Modulates proliferation and phosphorylation of c-Raf, MEK, ERK, JNK, and p38. Shows hepatoprotective and cardioprotective effects in vivo. Orally activ

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Nomi e identificatori

• Pubchem Sid: 528769790
• Sorrisi canonici: CC1CC2=CC3=C(C(=C2C4=C(C(=C(C=C4CC1C)OC)OC)OC)OC)OCO3
• IUPAC Name: 3,4,5,19-tetramethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.02,7.014,18]nonadeca-1(19),2,4,6,12,14(18)-hexaene
• InChIKey: RTZKSTLPRTWFEV-UHFFFAOYSA-N
• INCHI: 1S/C23H28O6/c1-12-7-14-9-16(24-3)20(25-4)22(26-5)18(14)19-15(8-13(12)2)10-17-21(23(19)27-6)29-11-28-17/h9-10,12-13H,7-8,11H2,1-6H3
• Isomeri SMILES: CC1CC2=CC3=C(C(=C2C4=C(C(=C(C=C4CC1C)OC)OC)OC)OC)OCO3
• PubChem CID: 108130
• Peso molecolare: 400.4648

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Phenylpropanoids and polyketides
    • Classe Tannins
      • Subclass Hydrolyzable tannins

• Kingdom: Organic compounds
• Superclass: Phenylpropanoids and polyketides
• Classe: Tannins
• Subclass: Hydrolyzable tannins
• Intermediate Tree Nodes: Not available
• Direct Parent: Hydrolyzable tannins
• Alternative Parents: Dibenzocyclooctadiene lignans Benzodioxoles Anisoles Alkyl aryl ethers Oxacyclic compounds Acetals Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Hydrolyzable tannin - Dibenzocyclooctane lignan - Benzodioxole - Anisole - Alkyl aryl ether - Benzenoid - Oxacycle - Organoheterocyclic compound - Ether - Acetal - Organic oxygen compound - Hydrocarbon derivative - Organooxygen compound - Aromatic heteropolycyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as hydrolyzable tannins. These are tannins with a structure characterized by either of the following models. In model 1, the structure contains galloyl units (in some cases, shikimic acid units) that are linked to diverse polyol carbohydrate-, catechin-, or triterpenoid units. In model 2, contains at least two galloyl units C-C coupled to each other, and do not contain a glycosidically linked catechin unit.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Obiettivi associati (umani)

PRKDC Tchem DNA-dependent protein kinase (1929 Activities)

Discover Target: PRKDC

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ATM Tchem Serine-protein kinase ATM (4198 Activities)

Discover Target: ATM

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ATR Tchem Serine-protein kinase ATR (986 Activities)

Discover Target: ATR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Obiettivi associati (non umani)

Abcc1 Multidrug resistance-associated protein 1 (42 Activities)

Discover Target: Abcc1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Meccanismi d'azione

Proprietà chimiche e fisiche

• Peso molecolare: 400.500 g/mol
• XLogP3: 5.100
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 4
• Exact Mass: 400.189 Da
• Monoisotopic Mass: 400.189 Da
• Topological Polar Surface Area: 55.400 Ų
• Heavy Atom Count: 29
• Formal Charge: 0
• Complexity: 543.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 2
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Riferimenti

1. Guangxu Cao, Shuang Li, Hezhan Shi, Peidi Yin, Jialing Chen, Huifeng Li, Ying Zhong, Li-Ting Diao, Bin Du.  (2019)  Schisandrin B attenuates renal fibrosis via miR-30e-mediated inhibition of EMT.  TOXICOLOGY AND APPLIED PHARMACOLOGY,      [PMID:31697999] [10.1016/j.taap.2019.114769]

2. Yuan Gao, Shimin Wu, Renhuai Cong, Junyong Xiao, Fangli Ma.  (2019)  Characterization of lignans in Schisandra chinensis oil with a single analysis process by UPLC-Q/TOF-MS.  CHEMISTRY AND PHYSICS OF LIPIDS,      [PMID:30610837] [10.1016/j.chemphyslip.2018.12.012]

3. Zhao Zijia, Gao Yan, Yuan Min, Ye Cai, Guo Yingxue, Zhao Yanli, Li Jinlian, Cui Jiwen, Dong Tianwei, Wu Dongmei.  (2024)  Application Prospects of Schisandra chinensis Fruit Post-Distillation Residues in Anti-Photoaging Products: Enhancing Anti-Photoaging Through Lignans Conversion.  Waste and Biomass Valorization,      [PMID:] [10.1007/s12649-024-02846-0]

4. Zhang Jinpeng, Cui Xinyuan, Zhao Shuo, Chang Zenghui, Zhang Junshuo, Chen Yufeng, Liu Jiale, Sun Guohao, Wang Yiyuan, Liu Yuanyuan.  (2024)  Establishment of a pharmacokinetics and pharmacodynamics model of Schisandra lignans against hippocampal neurotransmitters in AD rats based on microdi-alysis liquid chromatography-mass spectrometry.  Frontiers in Pharmacology,      [PMID:38529184] [10.3389/fphar.2024.1342121]

5. Shuang-Shuang Zhang, Jia-Hui Yu, Si-Si Jiang, Lun Wang, Jiong Chen, Jiao Long, Shuang-Xi Gu, Hui Li.  (2024)  T7 peptide-mediated co-delivery platform overcoming multidrug-resistant breast cancer: In vitro and in vivo evaluation.  EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,      [PMID:38759900] [10.1016/j.ejpb.2024.114327]

6. Jingwen Xu, Yijie Li, Ning Guo, Guangwen Luo, Le Wang, Jiaqi Wang, Jiayi Gao, Wanyang Qin, Lishan Yao, Guoliang Li.  (2025)  Schisandrin B loaded carrier with synergistic antioxidation alleviates Alzheimer’s disease in Caenorhabditis elegans by prolonging lifespan and inhibiting Aβ aggregation.  JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY,      [PMID:] [10.1016/j.jiec.2025.06.043]