QUALITÀ & PUREZZAMoligand™?Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.≥98%
Synonyms
2-(5-chloro-2-fluorophenyl)-4-(4-pyridylamino)pteridine|2-(5-Chloro-2-fluorophenyl)-4-[(4-pyridyl)amino]pteridine|[2-(5-Chloro-2-fluoro-phenyl)-pteridin-4-yl]-pyridin-4-yl-amine|2-(5-chloro-2-fluoro-phenyl)-N-(4-pyridyl)pteridin-4-amine|2-(5-Chloro-2-fluorophenyl)pteridin-4-yl]pyridin-4-yl-amine|SD208|SD-208|2-(5-chloro-2-fluorophenyl)-N-pyridin-4-ylpteridin-4-amine|2-(5-chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine|TGF- beta RI Kinase Inhibitor V|2-(5-Chloro-2-fluorophenyl)pteridin-4-yl)pyridin-4-yl amine|SD 208|2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-4-pteridinamine|4-Pteridinamine, 2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-|SCI-208
SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC50 of 48 nM, >100-fold selectivity over TGF-βRII. A TGF-β signaling blocker
Specifiche
Sinonimi
2-(5-chloro-2-fluorophenyl)-4-(4-pyridylamino)pteridine | 2-(5-Chloro-2-fluorophenyl)-4-[(4-pyridyl)amino]pteridine | [2-(5-Chloro-2-fluoro-phenyl)-pteridin-4-yl]-pyridin-4-yl-amine | 2-(5-chloro-2-fluoro-phenyl)-N-(4-pyridyl)pteridin-4-amine | 2-(5-Chloro-2-fluorophenyl)pteridin-4-yl]pyridin-4-yl-amine | SD208 | SD-208 | 2-(5-chloro-2-fl Mostra altro
Specifiche e purezza
Moligand™, ≥98%
Meccanismi biochimici e fisiologici
Potent, orally active ATP-competitive transforming growth factor-βreceptor 1 (TGF-βRI) inhibitor (IC50= 49 nM). Displays > 100-fold and > 17-fold selectivity over TGF-βRII and other common kinases respectively. Exhibits anti-inflammatory and antitumor act
Condizioni di conservazione di stoccaggio
Store at -20°C
Spedito in
Ice chest + Ice pads
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Grado
Moligand™
Tipo di azione
INHIBITOR
Meccanismo d'azione
Inhibitor of transforming growth factor beta receptor 1
This compound belongs to the class of organic compounds known as pteridines and derivatives. These are polycyclic aromatic compounds containing a pteridine moiety, which consists of a pyrimidine fused to a pyrazine ring to form pyrimido(4,5-b)pyrazine.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
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Recensioni
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E1718066