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Seconeolitsine - ≥95% , CAS No.2650074-56-7
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GRADE & PURITY ≥95%
Storage
Store at 2-8°C
Shipped In
Wet ice
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Why this grade
≥95% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
Seconeolitsine, an antibiotic , and is an inhibitor of targeting topoisomerase I (TopA) . Seconeolitsine also is a new antimicrobial agent that can inhibit S. pneumoniae growth. Seconeolitsine can inhibit TopA relaxation activity with an IC 50 value of 17 μM. Seconeolitsine can be used for the research of S. pneumoniae infections resistant to other antibiotics
In Vitro
Seconeolitsine (compounds 17) inhibits TopA relaxation activity in a concentration-dependent manner, with an IC 50 value of 17 μM and the inhibition of TopA is enhanced by preincubation of the enzyme with the alkaloid. Seconeolitsine shows great inhibition of S.pneumoniae growth with MIC 50 values of 16 μM for R6, ATCC6303, CipS8, CipS9, CipR20, CipR16, CipR8, CipR45 and CipR5. And shows great inhibition of S. pneumoniae growth with MIC 50 values of 8 μM for CipR42, CipR68 and CipR15. Seconeolitsine has activation at low concentrations and partial inhibition at 50 μM, a concentration at which the pneumococcal TopA showed full inhibition, but not inhibits Human TOPO1. Seconeolitsine (0.25×-1×MIC) affects cell growth and division in a concentration-dependent manner. Seconeolitsine (30 and 100 μM), is not affected neutrophil apoptosis and human cell viability. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Seconeolitsine (compounds 17) increases supercoiling and TopA is target in vivo . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:Topoisomerase I 17 μM (IC 50 )
Specifications
Specifications & Purity
≥95%
Biochemical and Physiological Mechanisms
Seconeolitsine, an antibiotic , and is an inhibitor of targeting topoisomerase I (TopA) . Seconeolitsine also is a new antimicrobial agent that can inhibit S. pneumoniae growth. Seconeolitsine can inhibit TopA relaxation activity with an IC 50 value of 17
Storage
Store at 2-8°C
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Purity
≥95%
Names and Identifiers
| Canonical Smiles | CNCCC1=C2C=CC3=CC(OCO4)=C4C=C3C2=C5OCOC5=C1 |
|---|---|
| Molecular Weight | 323.34 |
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
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