SI-109 - ≥99% , CAS No.2429877-30-3

CAS: 2429877-30-3 Cat. No.: S647472 Formula: C₄₀H₄₄F₂N₇O₉P Peso molecolare: 835.79

GRADE & PURITY ≥99%

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Panoramica

SI-109 is a potent STAT3 SH2 domain inhibitor ( K i =9 nM) with antitumor activity. SI-109 effectively inhibits the transcriptional activity of STAT3 ( IC 50 =3 μM). SI-109 and an analog of CRBN ligand lenalidomide have been used to design PROTAC STAT3 degrader SD-36

In Vitro

SI-109 exerts a moderate growth inhibitory activity in MOLM-16 cells (IC 50 =3 μM). SI-109 is ineffective in inhibition of STAT3 Y705 phosphorylation and in suppression of c-Myc expression at concentrations as high as 10 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:STAT3 9 nM (Ki)

Specifications

Specifiche e purezza

≥99%

Meccanismi biochimici e fisiologici

SI-109 is a potent STAT3 SH2 domain inhibitor ( K i =9 nM) with antitumor activity. SI-109 effectively inhibits the transcriptional activity of STAT3 ( IC 50 =3 μM). SI-109 and an analog of CRBN ligand lenalidomide have been used to design PROTAC STAT3 de

Condizioni di conservazione di stoccaggio

Store at -20°C,Argon charged

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Purezza

≥99%

Nomi e identificatori

• Peso molecolare: 835.79

Proprietà chimiche e fisiche

• Solubilità: DMSO : 150 mg/mL (179.47 mM; Need ultrasonic)