SI-109 - ≥99% , CAS No.2429877-30-3

CAS: 2429877-30-3 Cat. No.: S647472 Molecular Weight: 835.79

GRADE & PURITY ≥99%

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

SI-109 is a potent STAT3 SH2 domain inhibitor ( K i =9 nM) with antitumor activity. SI-109 effectively inhibits the transcriptional activity of STAT3 ( IC 50 =3 μM). SI-109 and an analog of CRBN ligand lenalidomide have been used to design PROTAC STAT3 degrader SD-36

In Vitro

SI-109 exerts a moderate growth inhibitory activity in MOLM-16 cells (IC 50 =3 μM). SI-109 is ineffective in inhibition of STAT3 Y705 phosphorylation and in suppression of c-Myc expression at concentrations as high as 10 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:STAT3 9 nM (Ki)

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

SI-109 is a potent STAT3 SH2 domain inhibitor ( K i =9 nM) with antitumor activity. SI-109 effectively inhibits the transcriptional activity of STAT3 ( IC 50 =3 μM). SI-109 and an analog of CRBN ligand lenalidomide have been used to design PROTAC STAT3 de

Storage

Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Names and Identifiers

• Molecular Weight: 835.79

Chemical and Physical Properties

• Solubility: DMSO : 150 mg/mL (179.47 mM; Need ultrasonic)