Silicified Microcrystalline Cellulose - JP, Ph.Eur., Colloidal anhydrous, E 460(i) and Silica, E 551, NF , CAS No.9004-34-6

CAS: 9004-34-6 Cat. No.: S489679 Formula: (C₆H₁₀O₅)_n Numero EC: 232-674-9 PubChem CID: 16211032

GRADE & PURITY JP, Ph.Eur., Colloidal anhydrous, E 460(i) and Silica, E 551, NF

Synonyms

cellulose|DEAE-CELLULOSE|9004-34-6|(6S)-2-(hydroxymethyl)-6-[(3S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol|Diethylaminoethyl cellulose|Cellulosepulver|DEAE-Sephacel(R)|Diethylaminoethyl-Sephacel(R)|CHEBI:156274|AKOS015895024|EN300-

Storage

Room temperature

Shipped In

Normal

Panoramica

Silicified Microcrystalline Cellulose, a unique complex of Microcrystalline Cellulose (MCC) and Colloidal Silicon Dioxide (CSD). A highly functional and multifunctional excipient that simplifies the process, and the inherent high functionality imparts effective functionality to the formulation. It has good fluidity, compressibility and dispersion in formulations. At the same time, it has two properties of brittle fracture and plastic deformation, and has better adhesion performance. The distribution of CSD particles in silicified microcrystalline cellulose is uniform, so the specific surface area is five times that of MCC, and the compressibility is improved by 30%-50%. The increase in specific surface area leads to better fluidity and compressibility, thereby improving formulation content uniformity and stability.

When used for direct compression, the granulation process can be omitted, and the types and amounts of auxiliary materials can also be greatly reduced, and excellent, uniform and cost-saving tablets can be prepared.

Product specifications

SKU	Average Particle Size by Laser Diffraction (µm)	Bulk Density (g/mL)	Main Application
S489679-01	65	0.25-0.37	Formulas in which optimal compaction and decent flow is required.
S489679-02	50	0.20-0.30	Best in class binder.
S489679-03	125	0.25-0.37	Formulas in which a balance of flow and compaction is required.
S489679-04	125	0.38-0.50	Formulas in which optimal flow and consolidation is required. This grade shows the best disintegration times. *Low moisture grade available on request.
S489679-05	125	0.27-0.39	Equivalent to quality of  SMCC 90, but with lower moisture content (< 3%)

Benefits

1.Excellent compactibility,

2.High intrinsic flow,

3.Enhanced lubrication efficiency,

4.Improved blending properties,

5.Superior binding properties,

6.Increased production capacity.

Specifications

Sinonimi

cellulose | DEAE-CELLULOSE | 9004-34-6 | (6S)-2-(hydroxymethyl)-6-[(3S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol | Diethylaminoethyl cellulose | Cellulosepulver | DEAE-Sephacel(R) | Diethylaminoethyl-Sephacel(R) | CHEBI:156274 | AKOS015895024 | EN300-

Specifiche e purezza

JP, Ph.Eur., Colloidal anhydrous, E 460(i) and Silica, E 551, NF

Condizioni di conservazione di stoccaggio

Room temperature

Spedito in

Normal

Grado

Colloidal anhydrous, E 460(i) and Silica, E 551, JP, NF, Ph.Eur.

Nomi e identificatori

Pubchem Sid

508815140

IUPAC Name

(6S)-2-(hydroxymethyl)-6-[(3S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol

InChIKey

GUBGYTABKSRVRQ-WFVLMXAXSA-N

INCHI

1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3?,4?,5?,6?,7?,8?,9?,10-,11?,12+/m1/s1

Isomeri SMILES

C(C1[C@H](C(C(C(O1)O)O)O)O[C@H]2C(C(C(C(O2)CO)O)O)O)O

WGK Germania

3

RTECS

FJ5691460

PubChem CID

16211032

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic oxygen compounds
    • Classe Organooxygen compounds
      • Subclass Carbohydrates and carbohydrate conjugates
        • Level5 Glycosyl compounds
          • Level6 O-glycosyl compounds

• Kingdom: Organic compounds
• Superclass: Organic oxygen compounds
• Classe: Organooxygen compounds
• Subclass: Carbohydrates and carbohydrate conjugates
• Intermediate Tree Nodes: Glycosyl compounds
• Direct Parent: O-glycosyl compounds
• Alternative Parents: Disaccharides Oxanes Secondary alcohols Hemiacetals Polyols Oxacyclic compounds Acetals Primary alcohols Hydrocarbon derivatives
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: O-glycosyl compound - Disaccharide - Oxane - Secondary alcohol - Hemiacetal - Oxacycle - Organoheterocyclic compound - Polyol - Acetal - Hydrocarbon derivative - Primary alcohol - Alcohol - Aliphatic heteromonocyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as o-glycosyl compounds. These are glycoside in which a sugar group is bonded through one carbon to another group via a O-glycosidic bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Proprietà chimiche e fisiche

• Peso molecolare: 342.300 g/mol
• XLogP3: -4.700
• Hydrogen Bond Donor Count: 8
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 4
• Exact Mass: 342.116 Da
• Monoisotopic Mass: 342.116 Da
• Topological Polar Surface Area: 190.000 Ų
• Heavy Atom Count: 23
• Formal Charge: 0
• Complexity: 382.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 2
• Undefined Atom Stereocenter Count: 8
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1