SIRT-IN-3 - Moligand™, 10mM in DMSO , CAS No.1211-19-4

CAS: 1211-19-4 Cat. No.: S655046 Formula: C₁₃H₁₂N₂O Peso molecolare: 212.25 PubChem CID: 96455

QUALITÀ & PUREZZA Moligand™, 10mM in DMSO

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

SIRT-IN-3 is a potent SIRT inhibitor, with an IC 50 of 17 μM for SIRT1. SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3 , respectively (IC 50 of 74 μM and 235 μM for SIRT2 and SIRT3 , respectively).

In Vitro

SIRT-IN-3 (Compound 7) (30-300 μM; 8 hours) causes p53 acetylation in in HCT116 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Specifiche

Specifiche e purezza

Moligand™, 10mM in DMSO

Meccanismi biochimici e fisiologici

SIRT-IN-3 is a potent SIRT inhibitor, with an IC 50 of 17 μM for SIRT1 . SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3 , respectively (IC 50 of 74 μM and 235 μM for SIRT2 and SIRT3 , respectively).

Condizioni di conservazione di stoccaggio

Protected from light,Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

INHIBITOR

Nomi e identificatori

Isomeri SMILES

C1=CC=C(C=C1)NC2=CC=CC=C2C(=O)N

PubChem CID

96455

Peso molecolare

212.25