SJF620 hydrochloride , CAS No.S659469

CAS: S659469 Cat. No.: S659469 Formula: C₄₁H₄₅ClN₈O₇ Peso molecolare: 797.3

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Panoramica

SJF620 hydrochloride is a PROTAC connected by ligands for Cereblon and Btk with a DC 50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN.

Appearance:Solid

IC50& Target:Cereblon

In Vitro:SJF620 hydrochloride is a PROTAC that retains potent degradation of BTK in cellular assays with a DC 50 of 7.9 nM in Burkitt lymphoma cell line NAMALWA. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo:SJF620 hydrochloride has a super pharmacokinetic profile in mice (1mg/kg; i.v.) with the half life (t 1/2 ) of 1.64 h. SJF620 exhibits a significantly better pharmacokinetic profile than MT802. MCE has not independently confirmed the accuracy of the

Biological Activity:SJF620 hydrochloride is a PROTAC connected by ligands for Cereblon and Btk with a DC 50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN.

Specifiche

Condizioni di conservazione di stoccaggio

Protected from light,Store at -20°C,Argon charged

Spedito in

Ice chest + Ice pads

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Nomi e identificatori

Peso molecolare

797.3