Smilagenin - 10mM in DMSO , CAS No.126-18-1

CAS: 126-18-1 Cat. No.: S656832 Formula: C₂₇H₄₄O₃ Peso molecolare: 416.64 Numero EC: 204-775-8 PubChem CID: 91439

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Smilagenin (SMI) is a small-molecule steroidal sapogenin from Anemarrhena asphodeloides and Pelargonium hortorum widely used in traditional Chinese medicine for treating chronic neurodegeneration diseases Smilagenin (SMI) improves memory of aged rats by increasing the muscarinic receptor subtype 1 (M1)-receptor densitySmilagenin (SMI) attenuates Aβ(25-35)-induced neurodegenerationvia stimulating the gene expression of brain-derived neurotrophic factor, may represents a novel therapeutic strategy for AD

In Vitro

Smilagenin (10 μM; 24 hours) increases SH-SY5Y cell survival compared with Aβ(25-35) intoxicated cells. Smilagenin (10 μM; 24 hours) increases neurotrophic factor (GDNF) and neurotrophic factor (BDNF) mRNA level by promoting CREB phosphorylation in 1-methyl-4-phenylpyridimium (MPP + ) treated SH-SY5Y cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: SH-SY5Y cells Concentration: 10 μM Incubation Time: 24 hours Result: Elevated the SH-SY5Y cell viability. RT-PCRCell Line: SH-SY5Y cells Concentration: 10 μM Incubation Time: 24 hours Result: Increased GDNF and BDNF transcription.

In Vivo

Smilagenin (intragastric administration; 10 or 26 mg/kg, once daily; 60 days) prevents the impairment of dopaminergic neurons in chronic MPTP/probenecid-induced mouse model. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: MPTP/probenecid-induced mouse modelDosage: 10 or 26 mg/kg Administration: Intragastric administration; 10 or 26 mg/kg; once daily; 60 days Result: Ameliorated locomotor ability of MPTP/probenecid-lesioned mice.

IC50& Target:mAChR1

Specifications

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

Smilagenin (SMI) is a small-molecule steroidal sapogenin from Anemarrhena asphodeloides and Pelargonium hortorum widely used in traditional Chinese medicine for treating chronic neurodegeneration diseases. \nSmilagenin (SMI) improves memory of aged r

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Nomi e identificatori

Isomeri SMILES

C[C@@H]1CC[C@@]2([C@H]([C@H]3[C@@H](O2)C[C@@H]4[C@@]3(CC[C@H]5[C@H]4CC[C@H]6[C@@]5(CC[C@@H](C6)O)C)C)C)OC1

CAS alternativo

126-18-1

PubChem CID

91439

Numero NSC

93747

Termini MeSH

epi-sarsasapogenin;epismilagenin;PYM 50028;PYM-50028;PYM50028;sarsaponin;sarsasapogenin;sarsasapogenin, (3beta,5alpha,25R)-isomer;sarsasapogenin, (3beta,5alpha,25S)-isomer;sarsasapogenin, (3beta,5beta)-isomer;sarsasapogenin, (3beta,5beta,25R)-isomer;sarsa

Peso molecolare

416.64

Domande frequenti

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 126-18-1, the molecular formula is C27H44O3, and the molecular weight is 416.64 g/mol.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.