Sodium Picosulfate - ≥98% , Stimulant laxative, CAS No.10040-45-6, Stimulant laxative

CAS: 10040-45-6 Cat. No.: S413087 Formula: C₁₈H₁₅NO₈S₂·2Na Peso molecolare: 481.41 Numero EC: 233-120-9 PubChem CID: 68654

GRADE & PURITY ≥98%

Synonyms

MFCD00867640 | SODIUM PICOSULFATE [INN] | LA 391 | Q410265 | Evacuol | 4,4'-(2-Picolylidene)bis(phenylsulfuric acid) disodium salt | Anhydrous Sodium Picosulfate | DTXSID7048663 | Natriumpicosulfat | LA-391 | Laxidogol | DA 1773 | Picoprep | S0936 | Evano

Storage

Store at 2-8°C

Shipped In

Wet ice

Panoramica

Information

Sodium Picosulfate inhibits absorption of water and electrolytes, and increases their secretion.

In vitro

Sodium Picosulfate displays cytotoxic effects on cultured liver cells. 800 and 1600 mg/mL induces dose-dependently vacuolic and fatty change as well as necrosis combined with a lowered mitotic activity and a slight increase in LDH values of the rapidly growing cultured liver cells of rabbit. Comparable but less severe effects are observed in 4-day old liver cell cultures of rat, while liver cells cultured for 6 to 11 days tolerate 1600 mg/mL Sodium Picosulfate. In human liver cultures the number of cells is slightly lowered at 800 and 1600 mg/mL and the number of nuclei in division is decreased dependent on dose.

In vivo

Sodium Picosulphate treatment for long-term has no effects on neuropeptide content of the rat colon. Over a 6-month period, daily doses (10 mg/kg/day) or twice-weekly doses (7.5 mg/kg/day) of Sodium Picosulphate do not affect the level of Vasoactive intestinal polypeptide (VIP), somatostatin, and substance P in mucosa, submucosa, or muscularis externa. Sodium Picosulphate has no major influence on ileal and colonic epithelial cell proliferation. In a 12 weeks study, 10 mg/kg Sodium Picosulphate continuously treatment does not influence the labeling index of Brdu (LI) in the ileum and induces no statistically significant increase of the LI when the treated groups are compared with the control group. The proliferative pattern along the crypts remains unchanged with sodium picosulphate treatment throughout the study. Sodium Picosulphate does not induce chronic changes in colonic motility in rats under long-term treatment. 10mg/kg/day Sodium Picosulphate pretreated for 23 weeks does not induce any significant change in the duration of long spike bursts (LSB) which are associated with phasic contractions, or in LSB frequency in the fasted state or after a 3-gram meal.

Specifications

Sinonimi

MFCD00867640 | SODIUM PICOSULFATE [INN] | LA 391 | Q410265 | Evacuol | 4,4'-(2-Picolylidene)bis(phenylsulfuric acid) disodium salt | Anhydrous Sodium Picosulfate | DTXSID7048663 | Natriumpicosulfat | LA-391 | Laxidogol | DA 1773 | Picoprep | S0936 | Evano

Specifiche e purezza

≥98%

Meccanismi biochimici e fisiologici

Sodium Picosulfate inhibits absorption of water and electrolytes, and increases their secretion.

Condizioni di conservazione di stoccaggio

Store at 2-8°C

Spedito in

Wet ice

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Meccanismo d'azione

Stimulant laxative

Purezza

≥98%

Nomi e identificatori

• Pubchem Sid: 504754303
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504754303
• Sorrisi canonici: C1=CC=NC(=C1)C(C2=CC=C(C=C2)OS(=O)(=O)[O-])C3=CC=C(C=C3)OS(=O)(=O)[O-].[Na+].[Na+]
• IUPAC Name: disodium;[4-[pyridin-2-yl-(4-sulfonatooxyphenyl)methyl]phenyl] sulfate
• InChIKey: GOZDTZWAMGHLDY-UHFFFAOYSA-L
• INCHI: 1S/C18H15NO8S2.2Na/c20-28(21,22)26-15-8-4-13(5-9-15)18(17-3-1-2-12-19-17)14-6-10-16(11-7-14)27-29(23,24)25;;/h1-12,18H,(H,20,21,22)(H,23,24,25);;/q;2*+1/p-2
• Isomeri SMILES: C1=CC=NC(=C1)C(C2=CC=C(C=C2)OS(=O)(=O)[O-])C3=CC=C(C=C3)OS(=O)(=O)[O-].[Na+].[Na+]
• PubChem CID: 68654
• Peso molecolare: 481.41

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Benzene and substituted derivatives
      • Subclass Diphenylmethanes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Benzene and substituted derivatives
• Subclass: Diphenylmethanes
• Intermediate Tree Nodes: Not available
• Direct Parent: Diphenylmethanes
• Alternative Parents: Phenylsulfates Phenoxy compounds Sulfuric acid monoesters Pyridines and derivatives Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Organic sodium salts Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Diphenylmethane - Phenylsulfate - Arylsulfate - Phenoxy compound - Pyridine - Sulfuric acid monoester - Sulfate-ester - Sulfuric acid ester - Organic sulfuric acid or derivatives - Heteroaromatic compound - Azacycle - Organic alkali metal salt - Organoheterocyclic compound - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organooxygen compound - Organonitrogen compound - Organic salt - Organic oxygen compound - Organic sodium salt - Aromatic heteromonocyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
• External Descriptors: pyridines - aryl sulfate

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Obiettivi associati (non umani)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Meccanismi d'azione

Proprietà chimiche e fisiche

• Solubilità: Solubility (25°C) In vitro DMSO: 96 mg/mL (199.41 mM); Water: 96 mg/mL (199.41 mM); Ethanol: 3 mg/mL (6.23 mM)
• Punto di fusione (°C): 273°C
• Peso molecolare: 481.400 g/mol
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 5
• Exact Mass: 480.988 Da
• Monoisotopic Mass: 480.988 Da
• Topological Polar Surface Area: 163.000 Ų
• Heavy Atom Count: 31
• Formal Charge: 0
• Complexity: 633.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

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