SRT1720 HCl - ≥98% , CAS No.1001645-58-4

CAS: 1001645-58-4 Cat. No.: S129890 Formula: C₂₅H₂₃N₇OS.HCl Peso molecolare: 506.02 PubChem CID: 25232708

GRADE & PURITY ≥98%

Synonyms

SRT 1720 Hydrochloride | BCP01774 | SRT-1720, SRT1720 | FT-0761472 | SRT1720 xHydrochloride | SCHEMBL16372055 | J-523315 | SRT1720 | DTXSID80649411 | J-000057 | N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide hydr

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Panoramica

SRT1720 is a selective SIRT1 activator with EC50 of 0.16 μM, but is >230-fold less potent for SIRT2 and SIRT3.
A selective SIRT1 activator

Specifications

Sinonimi

SRT 1720 Hydrochloride | BCP01774 | SRT-1720, SRT1720 | FT-0761472 | SRT1720 xHydrochloride | SCHEMBL16372055 | J-523315 | SRT1720 | DTXSID80649411 | J-000057 | N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide hydr

Specifiche e purezza

≥98%

Meccanismi biochimici e fisiologici

SRT1720 is an NAD-dependent deacetylase sirtuin-1 (SIRT1) activator (EC50 = 0.16 μM), highly selective for SIRT1 over SIRT2 or SIRT3. Studies in yeast suggest that sirtuins may be involved in epigentic gene silencing and deactylation of proteins that regu

Condizioni di conservazione di stoccaggio

Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Nota

Refer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purezza

≥98%

Nomi e identificatori

• Pubchem Sid: 504770034
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504770034
• Sorrisi canonici: C1CN(CCN1)CC2=CSC3=NC(=CN23)C4=CC=CC=C4NC(=O)C5=NC6=CC=CC=C6N=C5.Cl
• IUPAC Name: N-[2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide;hydrochloride
• InChIKey: DTGRRMPPXCRRIM-UHFFFAOYSA-N
• INCHI: 1S/C25H23N7OS.ClH/c33-24(22-13-27-20-7-3-4-8-21(20)28-22)29-19-6-2-1-5-18(19)23-15-32-17(16-34-25(32)30-23)14-31-11-9-26-10-12-31;/h1-8,13,15-16,26H,9-12,14H2,(H,29,33);1H
• Isomeri SMILES: C1CN(CCN1)CC2=CSC3=NC(=CN23)C4=CC=CC=C4NC(=O)C5=NC6=CC=CC=C6N=C5.Cl
• PubChem CID: 25232708
• Peso molecolare: 506.02

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Benzene and substituted derivatives
      • Subclass Anilides

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Benzene and substituted derivatives
• Subclass: Anilides
• Intermediate Tree Nodes: Not available
• Direct Parent: Aromatic anilides
• Alternative Parents: Phenylimidazoles Quinoxalines Pyrazinecarboxamides 2-heteroaryl carboxamides Aralkylamines N-alkylpiperazines N-substituted imidazoles Heteroaromatic compounds Thiazoles Trialkylamines Secondary carboxylic acid amides Amino acids and derivatives Dialkylamines Azacyclic compounds Organic oxides Hydrochlorides Hydrocarbon derivatives Organooxygen compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Aromatic anilide - 5-phenylimidazole - 4-phenylimidazole - Quinoxaline - Pyrazine carboxylic acid or derivatives - Pyrazinecarboxamide - 2-heteroaryl carboxamide - N-alkylpiperazine - Aralkylamine - 1,4-diazinane - N-substituted imidazole - Piperazine - Pyrazine - Thiazole - Heteroaromatic compound - Azole - Imidazole - Tertiary amine - Secondary carboxylic acid amide - Tertiary aliphatic amine - Carboxamide group - Amino acid or derivatives - Secondary amine - Organoheterocyclic compound - Azacycle - Carboxylic acid derivative - Secondary aliphatic amine - Hydrochloride - Organonitrogen compound - Amine - Organooxygen compound - Organic nitrogen compound - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Aromatic heteropolycyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as aromatic anilides. These are aromatic compounds containing an anilide group in which the carboxamide group is substituted with an aromatic group. They have the general structure RNC(=O)R', where R= benzene, and R = aryl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Obiettivi associati (umani)

AOX1 Tchem Aldehyde oxidase (429 Activities)

Discover Target: AOX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Meccanismi d'azione

Proprietà chimiche e fisiche

• Solubilità: DMSO 38 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
• Peso molecolare: 506.000 g/mol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 5
• Exact Mass: 505.145 Da
• Monoisotopic Mass: 505.145 Da
• Topological Polar Surface Area: 116.000 Ų
• Heavy Atom Count: 35
• Formal Charge: 0
• Complexity: 707.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

Domande frequenti

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1001645-58-4, the molecular formula is C25H23N7OS.HCl, and the molecular weight is 506.02 g/mol. InChIKey DTGRRMPPXCRRIM-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.