Stauprimide - ≥99% , CAS No.154589-96-5

CAS: 154589-96-5 Cat. No.: S139814 Formula: C₃₅H₂₈N₄O₅ Peso molecolare: 584.62 PubChem CID: 46245328

GRADE & PURITY ≥99%

Synonyms

Q7604751 | [9S-(9alpha,10beta,11beta,13alpha)]-N-(2,3,10,11,12,1 3-Hexahydro-10-methoxy-9-methyl-1,3-dioxo-9,13-epo xy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j] [1,7]benzodiazonin-11-yl)-N-methylbenzamide | HY-N6747 | N-((9S,10R,11R,13R)-2,3,10,1

Storage

Conservare a -20°C

Shipped In

Cassetta del ghiaccio + cuscini per il ghiaccio

Panoramica

La stauprimide è una piccola molecola semisintetica indolocarbazolica che ha dimostrato di aumentare significativamente l'efficienza della differenziazione diretta delle cellule staminali embrionali. La stauprimide inibisce la localizzazione nucleare di NME2, bloccando e downregolando l'espressione di c-Myc. L'espressione di c-Myc è fondamentale per l'auto-rinnovamento delle cellule staminali embrionali e l'intervento di Stauprimide consente una differenziazione più efficiente e specifica del lignaggio. NME2 è anche indicato come upregolato in alcuni tipi di cancro, il che indica un'ulteriore applicazione dell'azione bloccante di Stauprimide
Un indolocarbazolo promotore del differenziamento delle cellule staminali embrionali.

Specifications

Sinonimi

Q7604751 | [9S-(9alpha,10beta,11beta,13alpha)]-N-(2,3,10,11,12,1 3-Hexahydro-10-methoxy-9-methyl-1,3-dioxo-9,13-epo xy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j] [1,7]benzodiazonin-11-yl)-N-methylbenzamide | HY-N6747 | N-((9S,10R,11R,13R)-2,3,10,1

Specifiche e purezza

≥99%

Meccanismi biochimici e fisiologici

Piccola molecola che prepara le cellule staminali embrionali (ESC) alla differenziazione. Interagisce con NME2 e ne inibisce la traslocazione nucleare. Aumenta l'efficienza della differenziazione diretta di ESC di topo e umane in vitro.

Condizioni di conservazione di stoccaggio

Conservare a -20°C

Spedito in

Cassetta del ghiaccio + cuscini per il ghiaccio

Purezza

≥99%

Nomi e identificatori

Pubchem Sid

528767304

Sorrisi canonici

CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)C(=O)NC6=O)N(C)C(=O)C9=CC=CC=C9)OC

IUPAC Name

N-[(2S,3R,4R,6R)-3-methoxy-2-methyl-16,18-dioxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-N-methylbenzamide

InChIKey

MQCCJEYZKWZQHU-MPRCCEKMSA-N

INCHI

1S/C35H28N4O5/c1-35-31(43-3)23(37(2)34(42)18-11-5-4-6-12-18)17-24(44-35)38-21-15-9-7-13-19(21)25-27-28(33(41)36-32(27)40)26-20-14-8-10-16-22(20)39(35)30(26)29(25)38/h4-16,23-24,31H,17H2,1-3H3,(H,36,40,41)/t23-,24-,31-,35+/m1/s1

Isomeri SMILES

C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)C(=O)NC6=O)N(C)C(=O)C9=CC=CC=C9)OC

WGK Germania

3

PubChem CID

46245328

Peso molecolare

584.62

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Indoles and derivatives
      • Subclass Carbazoles
        • Level5 Pyrrolocarbazoles
          • Level6 Indolocarbazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Indoles and derivatives
• Subclass: Carbazoles
• Intermediate Tree Nodes: Pyrrolocarbazoles
• Direct Parent: Indolocarbazoles
• Alternative Parents: Pyrrolo[2,3-a]carbazoles Pyrroloindoles Phthalimides Benzamides Indoles Benzoyl derivatives Oxanes Tertiary carboxylic acid amides Pyrroles N-unsubstituted carboxylic acid imides Heteroaromatic compounds Tertiary amines Amino acids and derivatives Oxacyclic compounds Azacyclic compounds Dialkyl ethers Hydrocarbon derivatives Organic oxides
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Indolocarbazole - Pyrrolo[2,3-a]carbazole - Pyrroloindole - Phthalimide - Isoindolone - Benzamide - Benzoic acid or derivatives - Indole - Isoindoline - Isoindole or derivatives - Benzoyl - Monocyclic benzene moiety - Benzenoid - Oxane - Carboxylic acid imide - Heteroaromatic compound - Tertiary carboxylic acid amide - Carboxylic acid imide, n-unsubstituted - Pyrrole - Amino acid or derivatives - Carboxamide group - Tertiary amine - Azacycle - Oxacycle - Ether - Dialkyl ether - Carboxylic acid derivative - Amine - Hydrocarbon derivative - Organic oxide - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as indolocarbazoles. These are polycyclic aromatic compounds containing an indole fused to a carbazole.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Proprietà chimiche e fisiche

• Solubilità: Soluble in DMSO}
• Sensibilità: Light sensitive
• Punto di fusione (°C): 145°C
• Peso molecolare: 584.600 g/mol
• XLogP3: 4.800
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 584.206 Da
• Monoisotopic Mass: 584.206 Da
• Topological Polar Surface Area: 94.800 Ų
• Heavy Atom Count: 44
• Formal Charge: 0
• Complexity: 1220.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 4
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1