STF-62247 - ≥98% , CAS No.315702-99-9

CAS: 315702-99-9 Cat. No.: S129300 Formula: C₁₅H₁₃N₃S Peso molecolare: 267.35 Numero EC: 631-141-1 PubChem CID: 704473

GRADE & PURITY ≥98%

Synonyms

4-(pyridin-4-yl)-N-(m-tolyl)thiazol-2-amine | MFCD01121974 | KATNUHQNJGNLPW-UHFFFAOYSA-N | N-(3-methylphenyl)-4-pyridin-4-yl-2-thiazolamine | Oprea1_578909 | HMS3654K09 | DTXSID90351598 | J-018470 | SR-01000477178 | SR-01000477178-1 | SCHEMBL996232 | 4-(p

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Panoramica

STF-62247 is TGN inhibitor with IC50 of 0.625μM and 16μM in RCC4 and RCC4/VHL cells,respectively.It specifically induces autophagic cell death in cells that have lost VHL, an essential mutation in the development of RCC.
STF-62247 may be used as positive control in autophagy inducing cell signaling studies.

Specifications

Sinonimi

4-(pyridin-4-yl)-N-(m-tolyl)thiazol-2-amine | MFCD01121974 | KATNUHQNJGNLPW-UHFFFAOYSA-N | N-(3-methylphenyl)-4-pyridin-4-yl-2-thiazolamine | Oprea1_578909 | HMS3654K09 | DTXSID90351598 | J-018470 | SR-01000477178 | SR-01000477178-1 | SCHEMBL996232 | 4-(p

Specifiche e purezza

≥98%

Meccanismi biochimici e fisiologici

Autophagy Inducer, STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM). It significantly red

Condizioni di conservazione di stoccaggio

Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Purezza

≥98%

Nomi e identificatori

• Pubchem Sid: 528767214
• Sorrisi canonici: CC1=CC(=CC=C1)NC2=NC(=CS2)C3=CC=NC=C3
• IUPAC Name: N-(3-methylphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine
• InChIKey: KATNUHQNJGNLPW-UHFFFAOYSA-N
• INCHI: 1S/C15H13N3S/c1-11-3-2-4-13(9-11)17-15-18-14(10-19-15)12-5-7-16-8-6-12/h2-10H,1H3,(H,17,18)
• Isomeri SMILES: CC1=CC(=CC=C1)NC2=NC(=CS2)C3=CC=NC=C3
• WGK Germania: 2
• PubChem CID: 704473
• Peso molecolare: 267.35

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Benzene and substituted derivatives
      • Subclass Aniline and substituted anilines

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Benzene and substituted derivatives
• Subclass: Aniline and substituted anilines
• Intermediate Tree Nodes: Not available
• Direct Parent: Aniline and substituted anilines
• Alternative Parents: Toluenes 2,4-disubstituted thiazoles Pyridines and derivatives 2-amino-1,3-thiazoles Heteroaromatic compounds Secondary amines Azacyclic compounds Organopnictogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Aniline or substituted anilines - 2,4-disubstituted 1,3-thiazole - Toluene - Pyridine - 1,3-thiazol-2-amine - Azole - Heteroaromatic compound - Thiazole - Secondary amine - Azacycle - Organoheterocyclic compound - Hydrocarbon derivative - Organonitrogen compound - Organopnictogen compound - Organic nitrogen compound - Amine - Aromatic heteromonocyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as aniline and substituted anilines. These are organic compounds containing an aminobenzene moiety.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Obiettivi associati (umani)

GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

Discover Target: GLP1R

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786-0 (47912 Activities)

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HepG2 (196354 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HTT Tchem Huntingtin (19182 Activities)

Discover Target: HTT

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GMNN Tbio Geminin (128009 Activities)

Discover Target: GMNN

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RAB9A Tbio Ras-related protein Rab-9A (22488 Activities)

Discover Target: RAB9A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MBNL1 Tbio Muscleblind-like protein 1 (34431 Activities)

Discover Target: MBNL1

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microRNA 21 (64692 Activities)

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ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)

Discover Target: ATAD5

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MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)

Discover Target: MEN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TARDBP Tchem TAR DNA-binding protein 43 (40113 Activities)

Discover Target: TARDBP

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RCC4/VHL (23 Activities)

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Obiettivi associati (non umani)

Mapk1 MAP kinase ERK2 (650 Activities)

Discover Target: Mapk1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

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Plasmodium falciparum (966862 Activities)

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Luciferin 4-monooxygenase (66902 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Mapt Microtubule-associated protein tau (6 Activities)

Discover Target: Mapt

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FTL Ferritin light chain (43324 Activities)

Discover Target: FTL

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SARS-CoV-2 (38078 Activities)

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Vero C1008 (1716 Activities)

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Meccanismi d'azione

Proprietà chimiche e fisiche

• Solubilità: DMSO 53 mg/mL Water <1 mg/mL Ethanol 3 mg/mL
• Indice di rifrazione: 1.67
• Punto di ebollizione (°C): 444.82° C
• Punto di fusione (°C): 174.66°C
• Peso molecolare: 267.400 g/mol
• XLogP3: 3.800
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 267.083 Da
• Monoisotopic Mass: 267.083 Da
• Topological Polar Surface Area: 66.100 Ų
• Heavy Atom Count: 19
• Formal Charge: 0
• Complexity: 281.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Riferimenti

1. Xuehua Long, Huiqi Wang, Jianqin Yan, Yifei Li, Xue Dong, Sijia Tian, Yong Sun, Kui Luo, Bin He, Yan Liang.  (2023)  Tailor-Made Autophagy Cascade Amplification Polymeric Nanoparticles for Enhanced Tumor Immunotherapy.  Small,      [PMID:36932938] [10.1002/smll.202207898]