Streptolysin O - lyophilized powder,Protein ~3 % by Lowry,25,000-50,000 U/vial, from Streptococcus pyogenes , CAS No.98072-47-0

CAS: 98072-47-0 Cat. No.: S477654 Numero EC: 308-500-3 PubChem CID: 135280160

GRADE & PURITY lyophilized powder,Protein ~3 % by Lowry,25,000-50,000 U/vial, from Streptococcus pyogenes

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Panoramica

Description

Used to create holes (reversible pores) in cholesterol-enriched plasma membranes of eukaryotic cells allowing selective permeabilization with molecules such as proteins (up to 100 kDa) and siRNAs.Streptolysin O is a toxin secreted byStreptococcus pyogenesand is a prototype member of poreforming bacterial cytolysins. It is used permeabilize cell membranes to permit cellular uptake of large or charged molecules. It is used to study macromolecule delivery. It is a potential anticancer agent and is used to study suicide cancer gene therapy.Permeabilizes membranes to permit cellular uptake of large or charged molecules.

Preparation instructions

Form

Lyophilized powder containing Tris buffer salts, sodium azide, PMSF, and EDTA.

Principle

Specifications

Specifiche e purezza

lyophilized powder,Protein ~3 % by Lowry,25,000-50,000 U/vial, from Streptococcus pyogenes

Meccanismi biochimici e fisiologici

Streptolysin O possesses a single polypeptide chain with a molecular weight of f62 kDa. Streptolysin O binds to membrane cholesterol and oligomerizes to create a ring structure that consists of 45 to 50 units. The ring structure inserts into the membran

Condizioni di conservazione di stoccaggio

Store at 2-8°C,Desiccated

Spedito in

Wet ice

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Nomi e identificatori

• Pubchem Sid: 528776203
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/528776203
• WGK Germania: 3
• PubChem CID: 135280160

Proprietà chimiche e fisiche

• Solubilità: H2O: soluble 1mg/mL
• Sensibilità: Moisture Sensitive