Suprofen - Moligand™, 10mM in DMSO , Cyclooxygenase inhibitor, CAS No.40828-46-4, Cyclooxygenase inhibitor

CAS: 40828-46-4 Cat. No.: S408492 Formula: C₁₄H₁₂O₃S Peso molecolare: 260.31 Numero EC: 255-096-9 PubChem CID: 5359

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

α-​methyl-​4-​(2-​thienylcarbonyl)​-benzeneacetic acid

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Suprofen is a dualCOX-1/COX-2inhibitor, used as a non-steroidal anti-inflammatory analgesic and antipyretic.
In vitro

Suprofen inactivates the diclofenac-4-hydroxylase activity of baculovirus-expressed P450 2C9 in a time- and concentration-dependent manner, which is consistent with mechanism-based inactivation. Suprofen is a known generator of singlet oxygen whose participation in the reaction is supported by the effects of quenchers and scavengers. Suprofen photosensitizes the production of alkali-labile cleavage sites in DNA much more efficiently than direct strand breaks. Suprofen sensitizes photo-oxidation of cholesterol, producing 7 alpha- and 7 beta-hydroperoxides but not 5 alpha-hydroperoxide of cholesterol. Suprofen-sensitized photo-oxidation of membrane lipids of liposomes increases leakage of trapped glucose, suggesting photosensitized destabilization of the membrane structure. Suprofen incorporation in the phosphatidylcholine (PC) evaporation vesicles (REV) membrane leads to approximately 5% increase in the encapsulation efficiency (34%) in comparison to standard REV (29%).

In vivo

Suprofen combined with PGF2 alpha blocks induction of uterine contractions, suggesting the possibility that Suprofen also antagonizes PGF2 alpha receptor binding. Suprofen are effective at preventing BAB disruption after paracentesis in dogs, indicating their potential usefulness for treatment of prostaglandin-mediated ocular disease. Suprofen (3.7 mg/kg, i.v.) induces a marked decrease in the firing evoked in arthritic rats by ankle mobilization.
Cell Data

cell lines：HCC1806, MDA-MB-231, and T47D cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinonimi

α-​methyl-​4-​(2-​thienylcarbonyl)​-benzeneacetic acid

Specifiche e purezza

Moligand™, 10mM in DMSO

Meccanismi biochimici e fisiologici

Suprofen is a dual COX-1/COX-2 inhibitor, used as a non-steroidal anti-inflammatory analgesic and antipyretic.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

INHIBITOR

Meccanismo d'azione

Cyclooxygenase inhibitor

Proprietà del prodotto

• ALogP: 3.3

Nomi e identificatori

• Isomeri SMILES: CC(C1=CC=C(C=C1)C(=O)C2=CC=CS2)C(=O)O
• PubChem CID: 5359
• Peso molecolare: 260.31

Obiettivi associati (umani)

PTGS1 Tclin Prostaglandin G/H synthase 1 (2 Activities)

Discover Target: PTGS1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGS2 Tclin Prostaglandin G/H synthase 2 (1 Activities)

Discover Target: PTGS2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Proprietà chimiche e fisiche

• Solubilità: Solubility (25°C) In vitro Water: 42 mg/mL (200.35 mM); DMSO: Insoluble; Ethanol: Insoluble
• Punto di fusione (°C): 123 °C

Riferimenti

1. Yuanjing Lin, Jialiang Guo, Hang Lin, Jincai Wang, Govert W. Somsen, Jacques Crommen, Zhengjin Jiang.  (2017)  Effect of fabrication strategy on the enantioseparation performance of β-cyclodextrin-functionalized polymethacrylate monoliths: A comparative evaluation.  JOURNAL OF SEPARATION SCIENCE,  40  (19): (3754-3762).  [PMID:28749038] [10.1002/jssc.201700424]

2. Jialiang Guo, Yuan Xiao, Yuanjing Lin, Jacques Crommen, Zhengjin Jiang.  (2016)  Effect of the crosslinker type on the enantioseparation performance of β-cyclodextrin functionalized monoliths prepared by the one-pot approach.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:27268520] [10.1016/j.chroma.2016.05.078]

3. Jialiang Guo, Yuan Xiao, Yuanjing Lin, Qiaoxuan Zhang, Yiqun Chang, Jacques Crommen, Zhengjin Jiang.  (2016)  Influence of the linking spacer length and type on the enantioseparation ability of β-cyclodextrin functionalized monoliths.  TALANTA,      [PMID:26992519] [10.1016/j.talanta.2016.02.016]

Domande frequenti

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 40828-46-4, the molecular formula is C14H12O3S, and the molecular weight is 260.31 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.